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SMILES: Nc1ccc2c(ccnc2c1)-c1c2CCCn2nc1-c1ccccn1

InChI Key: InChIKey=IBIAUAYUNZFZJA-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50301179   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50301179
PNG
(4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]p...)
Show SMILES Nc1ccc2c(ccnc2c1)-c1c2CCCn2nc1-c1ccccn1 |(-7.41,-1.63,;-5.88,-1.79,;-4.97,-.54,;-3.45,-.7,;-2.83,-2.1,;-1.29,-2.26,;-.66,-3.66,;-1.56,-4.91,;-3.11,-4.75,;-3.73,-3.34,;-5.25,-3.18,;-.38,-1.02,;-.85,.45,;-2.11,1.34,;-1.64,2.81,;-.1,2.82,;.38,1.36,;1.64,.45,;1.16,-1.02,;2.06,-2.26,;1.43,-3.67,;2.33,-4.92,;3.87,-4.76,;4.5,-3.34,;3.59,-2.1,)|
Show InChI InChI=1S/C20H17N5/c21-13-6-7-14-15(8-10-23-17(14)12-13)19-18-5-3-11-25(18)24-20(19)16-4-1-2-9-22-16/h1-2,4,6-10,12H,3,5,11,21H2
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Article
PubMed
n/an/a 59n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of TGFR1

Eur J Med Chem 44: 4259-65 (2009)


Article DOI: 10.1016/j.ejmech.2009.07.008
BindingDB Entry DOI: 10.7270/Q2BC3ZM9
More data for this
Ligand-Target Pair