BindingDB PrimarySearch

BDBM50301311 (+/-)3,3,3-trifluoro-2-methyl-N-(8-morpholino-5,6,7,8-tetrahydronaphthalen-2-yl)-2-(trifluoromethyl)propanamide::3,3,3-trifluoro-2-methyl-N-(8-morpholino-5,6,7,8-tetrahydronaphthalen-2-yl)-2-(trifluoromethyl)propanamide::CHEMBL567594

SMILES: CC(C(=O)Nc1ccc2CCCC(N3CCOCC3)c2c1)(C(F)(F)F)C(F)(F)F

InChI Key: InChIKey=ILACWWPQONYUHT-UHFFFAOYSA-N

Data: 6 KI 3 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50301311
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Cannabinoid receptor 2 (Homo sapiens (Human))	BDBM50301311 ((+/-)3,3,3-trifluoro-2-methyl-N-(8-morpholino-5,6,...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	2.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Adolor Corporation Curated by ChEMBL					Assay Description Displacement of [3H]-CP-55940 from human CB2 receptor expressed in CHO cells				Bioorg Med Chem Lett 19: 5004-8 (2009) Article DOI: 10.1016/j.bmcl.2009.07.057 BindingDB Entry DOI: 10.7270/Q25M65S1
Adolor Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 2 (Homo sapiens (Human))	BDBM50301311 ((+/-)3,3,3-trifluoro-2-methyl-N-(8-morpholino-5,6,...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Adolor Corporation Curated by ChEMBL					Assay Description Displacement of [3H]-CP-55940 from human CB2 receptor expressed in CHO cells				Bioorg Med Chem Lett 19: 5004-8 (2009) Article DOI: 10.1016/j.bmcl.2009.07.057 BindingDB Entry DOI: 10.7270/Q25M65S1
Adolor Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 2 (Homo sapiens (Human))	BDBM50301311 ((+/-)3,3,3-trifluoro-2-methyl-N-(8-morpholino-5,6,...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	120	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Adolor Corporation Curated by ChEMBL					Assay Description Displacement of [3H]-CP-55940 from human CB2 receptor expressed in CHO cells				Bioorg Med Chem Lett 19: 5004-8 (2009) Article DOI: 10.1016/j.bmcl.2009.07.057 BindingDB Entry DOI: 10.7270/Q25M65S1
Adolor Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 1 (Homo sapiens (Human))	BDBM50301311 ((+/-)3,3,3-trifluoro-2-methyl-N-(8-morpholino-5,6,...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Adolor Corporation Curated by ChEMBL					Assay Description Displacement of [3H]-CP-55940 from human CB1 receptor expressed in CHO cells				Bioorg Med Chem Lett 19: 5004-8 (2009) Article DOI: 10.1016/j.bmcl.2009.07.057 BindingDB Entry DOI: 10.7270/Q25M65S1
Adolor Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 1 (Homo sapiens (Human))	BDBM50301311 ((+/-)3,3,3-trifluoro-2-methyl-N-(8-morpholino-5,6,...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	3.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Adolor Corporation Curated by ChEMBL					Assay Description Displacement of [3H]-CP-55940 from human CB1 receptor expressed in CHO cells				Bioorg Med Chem Lett 19: 5004-8 (2009) Article DOI: 10.1016/j.bmcl.2009.07.057 BindingDB Entry DOI: 10.7270/Q25M65S1
Adolor Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 1 (Homo sapiens (Human))	BDBM50301311 ((+/-)3,3,3-trifluoro-2-methyl-N-(8-morpholino-5,6,...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Adolor Corporation Curated by ChEMBL					Assay Description Displacement of [3H]-CP-55940 from human CB1 receptor expressed in CHO cells				Bioorg Med Chem Lett 19: 5004-8 (2009) Article DOI: 10.1016/j.bmcl.2009.07.057 BindingDB Entry DOI: 10.7270/Q25M65S1
Adolor Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 2 (Homo sapiens (Human))	BDBM50301311 ((+/-)3,3,3-trifluoro-2-methyl-N-(8-morpholino-5,6,...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	72	n/a	n/a	n/a	n/a
Adolor Corporation Curated by ChEMBL					Assay Description Agonist activity at human CB2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay				Bioorg Med Chem Lett 19: 5004-8 (2009) Article DOI: 10.1016/j.bmcl.2009.07.057 BindingDB Entry DOI: 10.7270/Q25M65S1
Adolor Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 2 (Homo sapiens (Human))	BDBM50301311 ((+/-)3,3,3-trifluoro-2-methyl-N-(8-morpholino-5,6,...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	41	n/a	n/a	n/a	n/a
Adolor Corporation Curated by ChEMBL					Assay Description Agonist activity at human CB2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay				Bioorg Med Chem Lett 19: 5004-8 (2009) Article DOI: 10.1016/j.bmcl.2009.07.057 BindingDB Entry DOI: 10.7270/Q25M65S1
Adolor Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 2 (Homo sapiens (Human))	BDBM50301311 ((+/-)3,3,3-trifluoro-2-methyl-N-(8-morpholino-5,6,...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	3.60	n/a	n/a	n/a	n/a
Adolor Corporation Curated by ChEMBL					Assay Description Agonist activity at human CB2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay				Bioorg Med Chem Lett 19: 5004-8 (2009) Article DOI: 10.1016/j.bmcl.2009.07.057 BindingDB Entry DOI: 10.7270/Q25M65S1
Adolor Corporation Curated by ChEMBL					More data for this Ligand-Target Pair