BDBM50301360 CHEMBL570643::N-(5-(6,7-dimethoxyquinolin-4-yloxy)pyridin-2-yl)-4-(4-methylpiperazin-1-yl)-2-oxo-1-phenyl-1,2-dihydropyridine-3-carboxamide

SMILES: COc1cc2nccc(Oc3ccc(NC(=O)c4c(ccn(-c5ccccc5)c4=O)N4CCN(C)CC4)nc3)c2cc1OC

InChI Key: InChIKey=KKIIRQGJRIUEDS-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50301360   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Focal adhesion kinase 1 (Homo sapiens (Human))	BDBM50301360 (CHEMBL570643 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...) Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4c(ccn(-c5ccccc5)c4=O)N4CCN(C)CC4)nc3)c2cc1OC Show InChI InChI=1S/C33H32N6O5/c1-37-15-17-38(18-16-37)26-12-14-39(22-7-5-4-6-8-22)33(41)31(26)32(40)36-30-10-9-23(21-35-30)44-27-11-13-34-25-20-29(43-3)28(42-2)19-24(25)27/h4-14,19-21H,15-18H2,1-3H3,(H,35,36,40)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.25E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human FAK by HTRF assay				Bioorg Med Chem Lett 19: 4924-8 (2009) Article DOI: 10.1016/j.bmcl.2009.07.084 BindingDB Entry DOI: 10.7270/Q2N017G2
					More data for this Ligand-Target Pair
PTK2B protein tyrosine kinase 2 beta (PTK2B) (Homo sapiens (Human))	BDBM50301360 (CHEMBL570643 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...) Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4c(ccn(-c5ccccc5)c4=O)N4CCN(C)CC4)nc3)c2cc1OC Show InChI InChI=1S/C33H32N6O5/c1-37-15-17-38(18-16-37)26-12-14-39(22-7-5-4-6-8-22)33(41)31(26)32(40)36-30-10-9-23(21-35-30)44-27-11-13-34-25-20-29(43-3)28(42-2)19-24(25)27/h4-14,19-21H,15-18H2,1-3H3,(H,35,36,40)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human Pyk2 by HTRF assay				Bioorg Med Chem Lett 19: 4924-8 (2009) Article DOI: 10.1016/j.bmcl.2009.07.084 BindingDB Entry DOI: 10.7270/Q2N017G2
					More data for this Ligand-Target Pair