BDBM50301361 CHEMBL570647::N-(5-(6,7-dimethoxyquinolin-4-yloxy)pyridin-2-yl)-2-oxo-1-phenyl-4-(phenylamino)-1,2-dihydropyridine-3-carboxamide

SMILES: COc1cc2nccc(Oc3ccc(NC(=O)c4c(Nc5ccccc5)ccn(-c5ccccc5)c4=O)nc3)c2cc1OC

InChI Key: InChIKey=WEEMSRUOVNMUPV-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50301361   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Focal adhesion kinase 1 (Homo sapiens (Human))	BDBM50301361 (CHEMBL570647 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...) Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4c(Nc5ccccc5)ccn(-c5ccccc5)c4=O)nc3)c2cc1OC Show InChI InChI=1S/C34H27N5O5/c1-42-29-19-25-27(20-30(29)43-2)35-17-15-28(25)44-24-13-14-31(36-21-24)38-33(40)32-26(37-22-9-5-3-6-10-22)16-18-39(34(32)41)23-11-7-4-8-12-23/h3-21,37H,1-2H3,(H,36,38,40)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human FAK by HTRF assay				Bioorg Med Chem Lett 19: 4924-8 (2009) Article DOI: 10.1016/j.bmcl.2009.07.084 BindingDB Entry DOI: 10.7270/Q2N017G2
					More data for this Ligand-Target Pair
PTK2B protein tyrosine kinase 2 beta (PTK2B) (Homo sapiens (Human))	BDBM50301361 (CHEMBL570647 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...) Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4c(Nc5ccccc5)ccn(-c5ccccc5)c4=O)nc3)c2cc1OC Show InChI InChI=1S/C34H27N5O5/c1-42-29-19-25-27(20-30(29)43-2)35-17-15-28(25)44-24-13-14-31(36-21-24)38-33(40)32-26(37-22-9-5-3-6-10-22)16-18-39(34(32)41)23-11-7-4-8-12-23/h3-21,37H,1-2H3,(H,36,38,40)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human Pyk2 by HTRF assay				Bioorg Med Chem Lett 19: 4924-8 (2009) Article DOI: 10.1016/j.bmcl.2009.07.084 BindingDB Entry DOI: 10.7270/Q2N017G2
					More data for this Ligand-Target Pair