BDBM50301543 CHEMBL566374::N-(4-(6-(ethylamino)pyrimidin-4-yl)thiazol-2-yl)-4-fluoro-N-methylbenzamide

SMILES: CCNc1cc(ncn1)-c1csc(n1)N(C)C(=O)c1ccc(F)cc1

InChI Key: InChIKey=VIMZQOMKOLTMJN-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50301543   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50301543 (CHEMBL566374 | N-(4-(6-(ethylamino)pyrimidin-4-yl)...) Show SMILES CCNc1cc(ncn1)-c1csc(n1)N(C)C(=O)c1ccc(F)cc1 Show InChI InChI=1S/C17H16FN5OS/c1-3-19-15-8-13(20-10-21-15)14-9-25-17(22-14)23(2)16(24)11-4-6-12(18)7-5-11/h4-10H,3H2,1-2H3,(H,19,20,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR5 receptor expressed in CHO cells by FLIPR assay				Bioorg Med Chem Lett 19: 5464-8 (2009) Article DOI: 10.1016/j.bmcl.2009.07.097 BindingDB Entry DOI: 10.7270/Q2W66KTT
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50301543 (CHEMBL566374 | N-(4-(6-(ethylamino)pyrimidin-4-yl)...) Show SMILES CCNc1cc(ncn1)-c1csc(n1)N(C)C(=O)c1ccc(F)cc1 Show InChI InChI=1S/C17H16FN5OS/c1-3-19-15-8-13(20-10-21-15)14-9-25-17(22-14)23(2)16(24)11-4-6-12(18)7-5-11/h4-10H,3H2,1-2H3,(H,19,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 receptor expressed in CHO cells by FLIPR assay				Bioorg Med Chem Lett 19: 5464-8 (2009) Article DOI: 10.1016/j.bmcl.2009.07.097 BindingDB Entry DOI: 10.7270/Q2W66KTT
					More data for this Ligand-Target Pair