BDBM50301804 5-(1-(2,4-difluorophenyl)-5-methyl-1H-1,2,3-triazol-4-yl)-2-isopropylisoindolin-1-one::CHEMBL579062
SMILES: CC(C)N1Cc2cc(ccc2C1=O)-c1nnn(c1C)-c1ccc(F)cc1F
InChI Key: InChIKey=KKZVYGIANGOHBS-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Metabotropic glutamate receptor 1 (Homo sapiens (Human)) | BDBM50301804 (5-(1-(2,4-difluorophenyl)-5-methyl-1H-1,2,3-triazo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute Curated by ChEMBL | Assay Description Antagonist activity at human mGluR1 receptor quisqualic acid binding site expressed in CHO cell membranes assessed as inhibition of L-glutamate-induc... | Bioorg Med Chem Lett 19: 5310-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.145 BindingDB Entry DOI: 10.7270/Q26H4HGN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GRM8 (Homo sapiens (Human)) | BDBM50301804 (5-(1-(2,4-difluorophenyl)-5-methyl-1H-1,2,3-triazo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute Curated by ChEMBL | Assay Description Antagonist activity at human mGluR8 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL... | Bioorg Med Chem Lett 19: 5310-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.145 BindingDB Entry DOI: 10.7270/Q26H4HGN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50301804 (5-(1-(2,4-difluorophenyl)-5-methyl-1H-1,2,3-triazo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute Curated by ChEMBL | Assay Description Antagonist activity at human mGluR2 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL... | Bioorg Med Chem Lett 19: 5310-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.145 BindingDB Entry DOI: 10.7270/Q26H4HGN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor (RAT) | BDBM50301804 (5-(1-(2,4-difluorophenyl)-5-methyl-1H-1,2,3-triazo...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute Curated by ChEMBL | Assay Description Antagonist activity at rat mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FLIP... | Bioorg Med Chem Lett 19: 5310-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.145 BindingDB Entry DOI: 10.7270/Q26H4HGN | |||||||||||
More data for this Ligand-Target Pair |