BDBM50301953 (3S,6S,9S,12S,15S,21S)-21-(2-((S)-2-amino-3-(1H-imidazol-5-yl)propanamido)-2-methylpropanamido)-3-((S)-1-((S)-1-amino-3-(2'-methylbiphenyl-4-yl)-1-oxopropan-2-ylamino)-3-(2'-ethyl-4'-methoxybiphenyl-4-yl)-1-oxopropan-2-ylcarbamoyl)-12-(2,6-difluorobenzyl)-9,15-bis((R)-1-hydroxyethyl)-6-(hydroxymethyl)-12-methyl-5,8,11,14,17,20-hexaoxo-4,7,10,13,16,19-hexaazatetracosane-1,24-dioic acid::CHEMBL577346
SMILES: CCc1cc(OC)ccc1-c1ccc(C[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@](C)(Cc2c(F)cccc2F)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](Cc2ccc(cc2)-c2ccccc2C)C(N)=O)cc1
InChI Key: InChIKey=MYDGXJGACGCIOQ-PLQWGJBVSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glucagon-like peptide 1 receptor (GLP-1) (Homo sapiens (Human)) | BDBM50301953 ((3S,6S,9S,12S,15S,21S)-21-(2-((S)-2-amino-3-(1H-im...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.660 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Queensland Curated by ChEMBL | Assay Description Displacement of [125I]-17 from human GLP-1R expressed in CHO cell membranes incubated for 120 mins by scintillation counting based radioligand bindin... | J Med Chem 58: 4080-5 (2015) Article DOI: 10.1021/acs.jmedchem.5b00166 BindingDB Entry DOI: 10.7270/Q2DB83KP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucagon-like peptide 1 receptor (Mus musculus) | BDBM50301953 ((3S,6S,9S,12S,15S,21S)-21-(2-((S)-2-amino-3-(1H-im...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company Research& Development Curated by ChEMBL | Assay Description Agonist activity at mouse GLP1R expressed in CHO cells assessed as stimulation of intracellular [3H]cAMP accumulation by scintillation proximity assa... | J Med Chem 52: 7788-99 (2009) Article DOI: 10.1021/jm900752a BindingDB Entry DOI: 10.7270/Q2VH5PRK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucagon-like peptide 1 receptor (GLP-1) (Homo sapiens (Human)) | BDBM50301953 ((3S,6S,9S,12S,15S,21S)-21-(2-((S)-2-amino-3-(1H-im...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0930 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company Research& Development Curated by ChEMBL | Assay Description Agonist activity at human GLP1R expressed in CHO cells assessed as stimulation of intracellular [3H]cAMP accumulation after 30 mins by scintillation ... | J Med Chem 52: 7788-99 (2009) Article DOI: 10.1021/jm900752a BindingDB Entry DOI: 10.7270/Q2VH5PRK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucagon-like peptide 1 receptor (GLP-1) (Homo sapiens (Human)) | BDBM50301953 ((3S,6S,9S,12S,15S,21S)-21-(2-((S)-2-amino-3-(1H-im...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.190 | n/a | n/a | n/a | n/a |
University of Queensland Curated by ChEMBL | Assay Description Agonist activity at human GLP-1R expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins | J Med Chem 58: 4080-5 (2015) Article DOI: 10.1021/acs.jmedchem.5b00166 BindingDB Entry DOI: 10.7270/Q2DB83KP | |||||||||||
More data for this Ligand-Target Pair |