BDBM50302100 3-(2-(2-acetyl-2-ethylhydrazinyl)-3,4-dioxocyclobut-1-enylamino)-2-hydroxy-N,N-dimethylbenzamide::CHEMBL576886
SMILES: CCN(Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)C(C)=O
InChI Key: InChIKey=NPEJHDQUNGKNRD-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
C-X-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM50302100 (3-(2-(2-acetyl-2-ethylhydrazinyl)-3,4-dioxocyclobu...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 320 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
WuXi PharmaTech Co. Ltd Curated by ChEMBL | Assay Description Displacement of [125I]IL-8 from human CXCR2 expressed in mouse BaF3 cells by liquid scintillation counting | Bioorg Med Chem Lett 19: 5741-5 (2009) Article DOI: 10.1016/j.bmcl.2009.08.014 BindingDB Entry DOI: 10.7270/Q25H7GB8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-X-C chemokine receptor type 1 (Homo sapiens (Human)) | BDBM50302100 (3-(2-(2-acetyl-2-ethylhydrazinyl)-3,4-dioxocyclobu...) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
WuXi PharmaTech Co. Ltd Curated by ChEMBL | Assay Description Displacement of [125I]IL-8 from human CXCR1 expressed in mouse BaF3 cells by liquid scintillation counting | Bioorg Med Chem Lett 19: 5741-5 (2009) Article DOI: 10.1016/j.bmcl.2009.08.014 BindingDB Entry DOI: 10.7270/Q25H7GB8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-X-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM50302100 (3-(2-(2-acetyl-2-ethylhydrazinyl)-3,4-dioxocyclobu...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
WuXi PharmaTech Co. Ltd Curated by ChEMBL | Assay Description Antagonist activity at CXCR2 expressed in CHO cells assessed as inhibition of IL-8-induced chemotaxis | Bioorg Med Chem Lett 19: 5741-5 (2009) Article DOI: 10.1016/j.bmcl.2009.08.014 BindingDB Entry DOI: 10.7270/Q25H7GB8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-X-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM50302100 (3-(2-(2-acetyl-2-ethylhydrazinyl)-3,4-dioxocyclobu...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.29E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
WuXi PharmaTech Co. Ltd Curated by ChEMBL | Assay Description Displacement of [125I]IL-8 from human CXCR2 expressed in mouse BaF3 cells by liquid scintillation counting | Bioorg Med Chem Lett 19: 5741-5 (2009) Article DOI: 10.1016/j.bmcl.2009.08.014 BindingDB Entry DOI: 10.7270/Q25H7GB8 | |||||||||||
More data for this Ligand-Target Pair |