BDBM50302101 3-(2-(2-ethyl-2-phenylhydrazinyl)-3,4-dioxocyclobut-1-enylamino)-2-hydroxy-N,N-dimethylbenzamide::CHEMBL570042

SMILES: CCN(Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccccc1

InChI Key: InChIKey=ZEKJNLVRFKSDCF-UHFFFAOYSA-N

Data: 2 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50302101   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50302101 (3-(2-(2-ethyl-2-phenylhydrazinyl)-3,4-dioxocyclobu...) Show SMILES CCN(Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccccc1 Show InChI InChI=1S/C21H22N4O4/c1-4-25(13-9-6-5-7-10-13)23-17-16(19(27)20(17)28)22-15-12-8-11-14(18(15)26)21(29)24(2)3/h5-12,22-23,26H,4H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	110	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
WuXi PharmaTech Co. Ltd Curated by ChEMBL					Assay Description Displacement of [125I]IL-8 from human CXCR2 expressed in mouse BaF3 cells by liquid scintillation counting				Bioorg Med Chem Lett 19: 5741-5 (2009) Article DOI: 10.1016/j.bmcl.2009.08.014 BindingDB Entry DOI: 10.7270/Q25H7GB8
					More data for this Ligand-Target Pair
C-X-C chemokine receptor type 1 (Homo sapiens (Human))	BDBM50302101 (3-(2-(2-ethyl-2-phenylhydrazinyl)-3,4-dioxocyclobu...) Show SMILES CCN(Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccccc1 Show InChI InChI=1S/C21H22N4O4/c1-4-25(13-9-6-5-7-10-13)23-17-16(19(27)20(17)28)22-15-12-8-11-14(18(15)26)21(29)24(2)3/h5-12,22-23,26H,4H2,1-3H3	PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	4.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
WuXi PharmaTech Co. Ltd Curated by ChEMBL					Assay Description Displacement of [125I]IL-8 from human CXCR1 expressed in mouse BaF3 cells by liquid scintillation counting				Bioorg Med Chem Lett 19: 5741-5 (2009) Article DOI: 10.1016/j.bmcl.2009.08.014 BindingDB Entry DOI: 10.7270/Q25H7GB8
					More data for this Ligand-Target Pair
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50302101 (3-(2-(2-ethyl-2-phenylhydrazinyl)-3,4-dioxocyclobu...) Show SMILES CCN(Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccccc1 Show InChI InChI=1S/C21H22N4O4/c1-4-25(13-9-6-5-7-10-13)23-17-16(19(27)20(17)28)22-15-12-8-11-14(18(15)26)21(29)24(2)3/h5-12,22-23,26H,4H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	54	n/a	n/a	n/a	n/a	n/a	n/a
WuXi PharmaTech Co. Ltd Curated by ChEMBL					Assay Description Antagonist activity at CXCR2 expressed in CHO cells assessed as inhibition of IL-8-induced chemotaxis				Bioorg Med Chem Lett 19: 5741-5 (2009) Article DOI: 10.1016/j.bmcl.2009.08.014 BindingDB Entry DOI: 10.7270/Q25H7GB8
					More data for this Ligand-Target Pair