BDBM50302254 CHEMBL565388::N-((R)-4-(3,4-dimethoxyphenyl)-4-(1,3-dioxo-4-(4-((R)-1-phenylethyl)piperazin-1-yl)isoindolin-2-yl)butyl)-3,5-dimethyl-1H-pyrazole-4-carboxamide

SMILES: COc1ccc(cc1OC)[C@@H](CCCNC(=O)c1c(C)n[nH]c1C)N1C(=O)c2cccc(N3CCN(CC3)[C@H](C)c3ccccc3)c2C1=O

InChI Key: InChIKey=CZWJHNWGEGYHNZ-PDDLMNHVSA-N

Data: 1 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50302254   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Urotensin II receptor (Homo sapiens (Human))	BDBM50302254 (CHEMBL565388 | N-((R)-4-(3,4-dimethoxyphenyl)-4-(1...) Show SMILES COc1ccc(cc1OC)[C@@H](CCCNC(=O)c1c(C)n[nH]c1C)N1C(=O)c2cccc(N3CCN(CC3)[C@H](C)c3ccccc3)c2C1=O |r| Show InChI InChI=1S/C38H44N6O5/c1-24-34(25(2)41-40-24)36(45)39-18-10-15-30(28-16-17-32(48-4)33(23-28)49-5)44-37(46)29-13-9-14-31(35(29)38(44)47)43-21-19-42(20-22-43)26(3)27-11-7-6-8-12-27/h6-9,11-14,16-17,23,26,30H,10,15,18-22H2,1-5H3,(H,39,45)(H,40,41)/t26-,30-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	87	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Displacement of [125I]urotensin 2 from urotensin 2 receptor in human RMS13 cells by scintillation proximity assay				J Med Chem 52: 7432-45 (2009) Article DOI: 10.1021/jm900683d BindingDB Entry DOI: 10.7270/Q2S75GD7
					More data for this Ligand-Target Pair
Urotensin II receptor (Homo sapiens (Human))	BDBM50302254 (CHEMBL565388 | N-((R)-4-(3,4-dimethoxyphenyl)-4-(1...) Show SMILES COc1ccc(cc1OC)[C@@H](CCCNC(=O)c1c(C)n[nH]c1C)N1C(=O)c2cccc(N3CCN(CC3)[C@H](C)c3ccccc3)c2C1=O |r| Show InChI InChI=1S/C38H44N6O5/c1-24-34(25(2)41-40-24)36(45)39-18-10-15-30(28-16-17-32(48-4)33(23-28)49-5)44-37(46)29-13-9-14-31(35(29)38(44)47)43-21-19-42(20-22-43)26(3)27-11-7-6-8-12-27/h6-9,11-14,16-17,23,26,30H,10,15,18-22H2,1-5H3,(H,39,45)(H,40,41)/t26-,30-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Antagonist activity at urotensin 2 receptor in human RMS13 cells assessed as inhibition of urotensin 2-induced intracellular calcium mobilization aft...				J Med Chem 52: 7432-45 (2009) Article DOI: 10.1021/jm900683d BindingDB Entry DOI: 10.7270/Q2S75GD7
					More data for this Ligand-Target Pair
UTS2R (RAT)	BDBM50302254 (CHEMBL565388 | N-((R)-4-(3,4-dimethoxyphenyl)-4-(1...) Show SMILES COc1ccc(cc1OC)[C@@H](CCCNC(=O)c1c(C)n[nH]c1C)N1C(=O)c2cccc(N3CCN(CC3)[C@H](C)c3ccccc3)c2C1=O |r| Show InChI InChI=1S/C38H44N6O5/c1-24-34(25(2)41-40-24)36(45)39-18-10-15-30(28-16-17-32(48-4)33(23-28)49-5)44-37(46)29-13-9-14-31(35(29)38(44)47)43-21-19-42(20-22-43)26(3)27-11-7-6-8-12-27/h6-9,11-14,16-17,23,26,30H,10,15,18-22H2,1-5H3,(H,39,45)(H,40,41)/t26-,30-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Antagonist activity at rat urotensin 2 receptor expressed in CHOK1 cells assessed as inhibition of urotensin 2-induced intracellular calcium mobiliza...				J Med Chem 52: 7432-45 (2009) Article DOI: 10.1021/jm900683d BindingDB Entry DOI: 10.7270/Q2S75GD7
					More data for this Ligand-Target Pair