BDBM50302265 (R)-N-(4-(4-(4-cyclopropylpiperazin-1-yl)-1-oxoisoindolin-2-yl)-4-(3,4-dimethoxyphenyl)butyl)-N-methylthiophene-2-sulfonamide::CHEMBL578204

SMILES: COc1ccc(cc1OC)[C@@H](CCCN(C)S(=O)(=O)c1cccs1)N1Cc2c(cccc2N2CCN(CC2)C2CC2)C1=O

InChI Key: InChIKey=WKSXYCNWZUFKAC-HHHXNRCGSA-N

Data: 1 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50302265   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Urotensin II receptor (Homo sapiens (Human))	BDBM50302265 ((R)-N-(4-(4-(4-cyclopropylpiperazin-1-yl)-1-oxoiso...) Show SMILES COc1ccc(cc1OC)[C@@H](CCCN(C)S(=O)(=O)c1cccs1)N1Cc2c(cccc2N2CCN(CC2)C2CC2)C1=O |r| Show InChI InChI=1S/C32H40N4O5S2/c1-33(43(38,39)31-10-6-20-42-31)15-5-9-27(23-11-14-29(40-2)30(21-23)41-3)36-22-26-25(32(36)37)7-4-8-28(26)35-18-16-34(17-19-35)24-12-13-24/h4,6-8,10-11,14,20-21,24,27H,5,9,12-13,15-19,22H2,1-3H3/t27-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	59	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Displacement of [125I]urotensin 2 from urotensin 2 receptor in human RMS13 cells by scintillation proximity assay				J Med Chem 52: 7432-45 (2009) Article DOI: 10.1021/jm900683d BindingDB Entry DOI: 10.7270/Q2S75GD7
					More data for this Ligand-Target Pair
Urotensin II receptor (Homo sapiens (Human))	BDBM50302265 ((R)-N-(4-(4-(4-cyclopropylpiperazin-1-yl)-1-oxoiso...) Show SMILES COc1ccc(cc1OC)[C@@H](CCCN(C)S(=O)(=O)c1cccs1)N1Cc2c(cccc2N2CCN(CC2)C2CC2)C1=O |r| Show InChI InChI=1S/C32H40N4O5S2/c1-33(43(38,39)31-10-6-20-42-31)15-5-9-27(23-11-14-29(40-2)30(21-23)41-3)36-22-26-25(32(36)37)7-4-8-28(26)35-18-16-34(17-19-35)24-12-13-24/h4,6-8,10-11,14,20-21,24,27H,5,9,12-13,15-19,22H2,1-3H3/t27-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Antagonist activity at urotensin 2 receptor in human RMS13 cells assessed as inhibition of urotensin 2-induced intracellular calcium mobilization aft...				J Med Chem 52: 7432-45 (2009) Article DOI: 10.1021/jm900683d BindingDB Entry DOI: 10.7270/Q2S75GD7
					More data for this Ligand-Target Pair
UTS2R (RAT)	BDBM50302265 ((R)-N-(4-(4-(4-cyclopropylpiperazin-1-yl)-1-oxoiso...) Show SMILES COc1ccc(cc1OC)[C@@H](CCCN(C)S(=O)(=O)c1cccs1)N1Cc2c(cccc2N2CCN(CC2)C2CC2)C1=O |r| Show InChI InChI=1S/C32H40N4O5S2/c1-33(43(38,39)31-10-6-20-42-31)15-5-9-27(23-11-14-29(40-2)30(21-23)41-3)36-22-26-25(32(36)37)7-4-8-28(26)35-18-16-34(17-19-35)24-12-13-24/h4,6-8,10-11,14,20-21,24,27H,5,9,12-13,15-19,22H2,1-3H3/t27-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Antagonist activity at rat urotensin 2 receptor expressed in CHOK1 cells assessed as inhibition of urotensin 2-induced intracellular calcium mobiliza...				J Med Chem 52: 7432-45 (2009) Article DOI: 10.1021/jm900683d BindingDB Entry DOI: 10.7270/Q2S75GD7
					More data for this Ligand-Target Pair