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BDBM50302606 (2S,3R,4R,5R)-2-[4-Chloro-3-(4-ethoxy-benzyl)-phenyl]-5-fluoro-6-methoxy-tetrahydro-pyran-3,4-diol::CHEMBL566940

SMILES: CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2OC(OC)[C@H](F)[C@H](O)[C@H]2O)cc1

InChI Key: InChIKey=JFVIJDSBSHXAJV-DQKSBWHRSA-N

Data: 2 IC50

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50302606   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
sodium-dependent glucose cotransporter 2 (SGLT2)


(Mus musculus (Mouse))
BDBM50302606
PNG
((2S,3R,4R,5R)-2-[4-Chloro-3-(4-ethoxy-benzyl)-phen...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2OC(OC)[C@H](F)[C@H](O)[C@H]2O)cc1 |r|
Show InChI InChI=1S/C21H24ClFO5/c1-3-27-15-7-4-12(5-8-15)10-14-11-13(6-9-16(14)22)20-19(25)18(24)17(23)21(26-2)28-20/h4-9,11,17-21,24-25H,3,10H2,1-2H3/t17-,18+,19-,20+,21?/m1/s1
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PC sid
UniChem

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Article
PubMed
n/an/a 220n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of mouse SGLT2-mediated [14C]alpha-methylglucopyranoside uptake by cell based assay


J Med Chem 52: 6201-4 (2009)


Article DOI: 10.1021/jm900951n
BindingDB Entry DOI: 10.7270/Q2F76DH1
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50302606
PNG
((2S,3R,4R,5R)-2-[4-Chloro-3-(4-ethoxy-benzyl)-phen...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2OC(OC)[C@H](F)[C@H](O)[C@H]2O)cc1 |r|
Show InChI InChI=1S/C21H24ClFO5/c1-3-27-15-7-4-12(5-8-15)10-14-11-13(6-9-16(14)22)20-19(25)18(24)17(23)21(26-2)28-20/h4-9,11,17-21,24-25H,3,10H2,1-2H3/t17-,18+,19-,20+,21?/m1/s1
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 600n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in HEK293 cells assessed as inhibition of [14C]alpha-methylglucopyranoside uptake


J Med Chem 52: 6201-4 (2009)


Article DOI: 10.1021/jm900951n
BindingDB Entry DOI: 10.7270/Q2F76DH1
More data for this
Ligand-Target Pair