new BindingDB logo
myBDB logout

BDBM50302608 (3S,4R,5R,6S)-2-(benzyloxy)-6-(4-chloro-3-(4-ethoxybenzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triol::CHEMBL567778

SMILES: CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2OC(OCc3ccccc3)[C@@H](O)[C@H](O)[C@H]2O)cc1

InChI Key: InChIKey=QKEQDXYUUYYDDR-HKQFDGPLSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50302608   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
sodium-dependent glucose cotransporter 2 (SGLT2)


(Mus musculus (Mouse))
BDBM50302608
PNG
((3S,4R,5R,6S)-2-(benzyloxy)-6-(4-chloro-3-(4-ethox...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2OC(OCc3ccccc3)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r|
Show InChI InChI=1S/C27H29ClO6/c1-2-32-21-11-8-17(9-12-21)14-20-15-19(10-13-22(20)28)26-24(30)23(29)25(31)27(34-26)33-16-18-6-4-3-5-7-18/h3-13,15,23-27,29-31H,2,14,16H2,1H3/t23-,24-,25+,26+,27?/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 330n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of mouse SGLT2-mediated [14C]alpha-methylglucopyranoside uptake by cell based assay


J Med Chem 52: 6201-4 (2009)


Article DOI: 10.1021/jm900951n
BindingDB Entry DOI: 10.7270/Q2F76DH1
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50302608
PNG
((3S,4R,5R,6S)-2-(benzyloxy)-6-(4-chloro-3-(4-ethox...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2OC(OCc3ccccc3)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r|
Show InChI InChI=1S/C27H29ClO6/c1-2-32-21-11-8-17(9-12-21)14-20-15-19(10-13-22(20)28)26-24(30)23(29)25(31)27(34-26)33-16-18-6-4-3-5-7-18/h3-13,15,23-27,29-31H,2,14,16H2,1H3/t23-,24-,25+,26+,27?/m1/s1
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 620n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in HEK293 cells assessed as inhibition of [14C]alpha-methylglucopyranoside uptake


J Med Chem 52: 6201-4 (2009)


Article DOI: 10.1021/jm900951n
BindingDB Entry DOI: 10.7270/Q2F76DH1
More data for this
Ligand-Target Pair