BDBM50302612 CHEMBL568609::O-4-(2-Chloro-5-((2S,3R,4R,5S)-3,4,5-trihydroxy-6-methoxytetrahydro-2H-pyran-2-yl)benzyl)phenyl dimethylcarbamothioate

SMILES: COC1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OC(=S)N(C)C)cc2)c1

InChI Key: InChIKey=ZEWWRYWRLJNZMV-AUGMSIGLSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50302612   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
sodium-dependent glucose cotransporter 2 (SGLT2) (Mus musculus (Mouse))	BDBM50302612 (CHEMBL568609 | O-4-(2-Chloro-5-((2S,3R,4R,5S)-3,4,...) Show SMILES COC1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OC(=S)N(C)C)cc2)c1 |r| Show InChI InChI=1S/C22H26ClNO6S/c1-24(2)22(31)29-15-7-4-12(5-8-15)10-14-11-13(6-9-16(14)23)20-18(26)17(25)19(27)21(28-3)30-20/h4-9,11,17-21,25-27H,10H2,1-3H3/t17-,18-,19+,20+,21?/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	330	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibition of mouse SGLT2-mediated [14C]alpha-methylglucopyranoside uptake by cell based assay				J Med Chem 52: 6201-4 (2009) Article DOI: 10.1021/jm900951n BindingDB Entry DOI: 10.7270/Q2F76DH1
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM50302612 (CHEMBL568609 | O-4-(2-Chloro-5-((2S,3R,4R,5S)-3,4,...) Show SMILES COC1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OC(=S)N(C)C)cc2)c1 |r| Show InChI InChI=1S/C22H26ClNO6S/c1-24(2)22(31)29-15-7-4-12(5-8-15)10-14-11-13(6-9-16(14)23)20-18(26)17(25)19(27)21(28-3)30-20/h4-9,11,17-21,25-27H,10H2,1-3H3/t17-,18-,19+,20+,21?/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	740	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibition of human SGLT2 expressed in HEK293 cells assessed as inhibition of [14C]alpha-methylglucopyranoside uptake				J Med Chem 52: 6201-4 (2009) Article DOI: 10.1021/jm900951n BindingDB Entry DOI: 10.7270/Q2F76DH1
					More data for this Ligand-Target Pair