BDBM50302884 CHEMBL570793::N-((3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl)-4-(3-oxo-2,3-dihydropyridazin-4-yl)piperidine-1-carboxamide

SMILES: Fc1cccc([C@@H]2CC[C@@H](NC(=O)N3CCC(CC3)c3ccn[nH]c3=O)C(=O)N(CC(F)(F)F)C2)c1F

InChI Key: InChIKey=FJPBDMFBVGVUFP-DNVCBOLYSA-N

Data: 1 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50302884   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcitonin gene-related peptide type 1 receptor (Homo sapiens (Human))	BDBM50302884 (CHEMBL570793 | N-((3R,6S)-6-(2,3-difluorophenyl)-2...) Show SMILES Fc1cccc([C@@H]2CC[C@@H](NC(=O)N3CCC(CC3)c3ccn[nH]c3=O)C(=O)N(CC(F)(F)F)C2)c1F |r| Show InChI InChI=1S/C24H26F5N5O3/c25-18-3-1-2-16(20(18)26)15-4-5-19(22(36)34(12-15)13-24(27,28)29)31-23(37)33-10-7-14(8-11-33)17-6-9-30-32-21(17)35/h1-3,6,9,14-15,19H,4-5,7-8,10-13H2,(H,31,37)(H,32,35)/t15-,19-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]human CGRP from human CLR expressed in HEK 293 cells coexpressing human RAMP1 after 3 hrs by scintillation counting				Bioorg Med Chem Lett 19: 6368-72 (2009) Article DOI: 10.1016/j.bmcl.2009.09.066 BindingDB Entry DOI: 10.7270/Q2PC32FD
					More data for this Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor (Homo sapiens (Human))	BDBM50302884 (CHEMBL570793 | N-((3R,6S)-6-(2,3-difluorophenyl)-2...) Show SMILES Fc1cccc([C@@H]2CC[C@@H](NC(=O)N3CCC(CC3)c3ccn[nH]c3=O)C(=O)N(CC(F)(F)F)C2)c1F |r| Show InChI InChI=1S/C24H26F5N5O3/c25-18-3-1-2-16(20(18)26)15-4-5-19(22(36)34(12-15)13-24(27,28)29)31-23(37)33-10-7-14(8-11-33)17-6-9-30-32-21(17)35/h1-3,6,9,14-15,19H,4-5,7-8,10-13H2,(H,31,37)(H,32,35)/t15-,19-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production...				Bioorg Med Chem Lett 19: 6368-72 (2009) Article DOI: 10.1016/j.bmcl.2009.09.066 BindingDB Entry DOI: 10.7270/Q2PC32FD
					More data for this Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor (Homo sapiens (Human))	BDBM50302884 (CHEMBL570793 | N-((3R,6S)-6-(2,3-difluorophenyl)-2...) Show SMILES Fc1cccc([C@@H]2CC[C@@H](NC(=O)N3CCC(CC3)c3ccn[nH]c3=O)C(=O)N(CC(F)(F)F)C2)c1F |r| Show InChI InChI=1S/C24H26F5N5O3/c25-18-3-1-2-16(20(18)26)15-4-5-19(22(36)34(12-15)13-24(27,28)29)31-23(37)33-10-7-14(8-11-33)17-6-9-30-32-21(17)35/h1-3,6,9,14-15,19H,4-5,7-8,10-13H2,(H,31,37)(H,32,35)/t15-,19-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	112	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production...				Bioorg Med Chem Lett 19: 6368-72 (2009) Article DOI: 10.1016/j.bmcl.2009.09.066 BindingDB Entry DOI: 10.7270/Q2PC32FD
					More data for this Ligand-Target Pair