BDBM50303059 3-(6-(benzylamino)pyrimidin-4-yl)pyrazolo[1,5-a]pyrimidin-2-amine::CHEMBL570890

SMILES: Nc1nn2cccnc2c1-c1cc(NCc2ccccc2)ncn1

InChI Key: InChIKey=SQORTIXACHFWII-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50303059   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50303059 (3-(6-(benzylamino)pyrimidin-4-yl)pyrazolo[1,5-a]py...) Show SMILES Nc1nn2cccnc2c1-c1cc(NCc2ccccc2)ncn1 Show InChI InChI=1S/C17H15N7/c18-16-15(17-19-7-4-8-24(17)23-16)13-9-14(22-11-21-13)20-10-12-5-2-1-3-6-12/h1-9,11H,10H2,(H2,18,23)(H,20,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 19: 6529-33 (2009) Article DOI: 10.1016/j.bmcl.2009.10.053 BindingDB Entry DOI: 10.7270/Q2SJ1MKQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50303059 (3-(6-(benzylamino)pyrimidin-4-yl)pyrazolo[1,5-a]py...) Show SMILES Nc1nn2cccnc2c1-c1cc(NCc2ccccc2)ncn1 Show InChI InChI=1S/C17H15N7/c18-16-15(17-19-7-4-8-24(17)23-16)13-9-14(22-11-21-13)20-10-12-5-2-1-3-6-12/h1-9,11H,10H2,(H2,18,23)(H,20,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc Curated by ChEMBL					Assay Description Inhibition of JAK2-mediated STAT5 phosphorylation in GMCSF-stimulated human TF1 cells				Bioorg Med Chem Lett 19: 6529-33 (2009) Article DOI: 10.1016/j.bmcl.2009.10.053 BindingDB Entry DOI: 10.7270/Q2SJ1MKQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50303059 (3-(6-(benzylamino)pyrimidin-4-yl)pyrazolo[1,5-a]py...) Show SMILES Nc1nn2cccnc2c1-c1cc(NCc2ccccc2)ncn1 Show InChI InChI=1S/C17H15N7/c18-16-15(17-19-7-4-8-24(17)23-16)13-9-14(22-11-21-13)20-10-12-5-2-1-3-6-12/h1-9,11H,10H2,(H2,18,23)(H,20,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	54	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc Curated by ChEMBL					Assay Description Inhibition of JAK3 by radiometric assay				Bioorg Med Chem Lett 19: 6529-33 (2009) Article DOI: 10.1016/j.bmcl.2009.10.053 BindingDB Entry DOI: 10.7270/Q2SJ1MKQ
					More data for this Ligand-Target Pair