BDBM50303110 CHEMBL585334::ethyl 3-(3-(1H-indazol-4-yl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidin-7-yl)-8-azabicyclo[3.2.1]octane-8-carboxylate

SMILES: CCOC(=O)N1C2CCC1CC(C2)c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12

InChI Key: InChIKey=NGWVISUMTZXJND-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50303110   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50303110 (CHEMBL585334 | ethyl 3-(3-(1H-indazol-4-yl)-2-(pyr...) Show SMILES CCOC(=O)N1C2CCC1CC(C2)c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 |THB:13:11:5:7.8,(16.08,-21.46,;14.76,-22.25,;13.41,-21.51,;12.09,-22.3,;10.75,-21.56,;12.12,-23.84,;11.59,-25.31,;10.07,-25.99,;11.44,-25.95,;12.63,-25.09,;14.17,-25.94,;13.63,-27.41,;13.18,-26.22,;13.63,-28.95,;12.3,-29.72,;12.3,-31.26,;13.63,-32.03,;14.97,-31.26,;16.44,-31.73,;17.35,-30.49,;16.44,-29.23,;14.97,-29.71,;18.88,-30.48,;19.65,-31.82,;21.19,-31.82,;21.96,-30.48,;21.18,-29.15,;19.65,-29.15,;16.51,-33.27,;15.21,-34.09,;15.27,-35.64,;16.63,-36.35,;17.94,-35.53,;19.43,-35.94,;20.29,-34.65,;19.32,-33.44,;17.87,-33.98,)| Show InChI InChI=1S/C28H27N7O2/c1-2-37-28(36)34-19-6-7-20(34)15-18(14-19)24-10-13-30-27-25(21-4-3-5-23-22(21)16-31-32-23)26(33-35(24)27)17-8-11-29-12-9-17/h3-5,8-13,16,18-20H,2,6-7,14-15H2,1H3,(H,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of B-Raf				Bioorg Med Chem Lett 19: 6957-61 (2009) Article DOI: 10.1016/j.bmcl.2009.10.058 BindingDB Entry DOI: 10.7270/Q2833S34
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