BDBM50303122 3-(7-chloro-1H-indazol-4-yl)-7-(8-ethyl-8-azabicyclo[3.2.1]octan-3-yl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidine::CHEMBL583245

SMILES: CCN1C2CCC1CC(C2)c1ccnc2c(c(nn12)-c1ccncc1)-c1ccc(Cl)c2[nH]ncc12

InChI Key: InChIKey=IUBYJXRDWGEBMX-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50303122   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50303122 (3-(7-chloro-1H-indazol-4-yl)-7-(8-ethyl-8-azabicyc...) Show SMILES CCN1C2CCC1CC(C2)c1ccnc2c(c(nn12)-c1ccncc1)-c1ccc(Cl)c2[nH]ncc12 |THB:10:8:2:4.5,(-4.54,-15.7,;-5.86,-16.5,;-5.83,-18.03,;-6.37,-19.5,;-7.89,-20.18,;-6.52,-20.15,;-5.33,-19.28,;-3.79,-20.13,;-4.33,-21.6,;-4.77,-20.41,;-4.33,-23.14,;-5.65,-23.91,;-5.66,-25.45,;-4.32,-26.22,;-2.99,-25.45,;-1.52,-25.93,;-.6,-24.68,;-1.52,-23.42,;-2.99,-23.9,;.93,-24.68,;1.7,-26.01,;3.23,-26.01,;4.01,-24.68,;3.23,-23.34,;1.69,-23.35,;-1.45,-27.47,;-2.75,-28.29,;-2.69,-29.83,;-1.33,-30.55,;-1.27,-32.09,;-.02,-29.73,;1.48,-30.14,;2.33,-28.84,;1.36,-27.63,;-.09,-28.18,)| Show InChI InChI=1S/C27H26ClN7/c1-2-34-18-3-4-19(34)14-17(13-18)23-9-12-30-27-24(20-5-6-22(28)26-21(20)15-31-32-26)25(33-35(23)27)16-7-10-29-11-8-16/h5-12,15,17-19H,2-4,13-14H2,1H3,(H,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of B-Raf				Bioorg Med Chem Lett 19: 6957-61 (2009) Article DOI: 10.1016/j.bmcl.2009.10.058 BindingDB Entry DOI: 10.7270/Q2833S34
					More data for this Ligand-Target Pair