BDBM50303124 7-(8-azabicyclo[3.2.1]octan-3-yl)-3-(7-fluoro-1H-indazol-4-yl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidine::CHEMBL584527

SMILES: Fc1ccc(-c2c(nn3c(ccnc23)C2CC3CCC(C2)N3)-c2ccncc2)c2cn[nH]c12

InChI Key: InChIKey=QMRARKCWJXXDNO-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50303124   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50303124 (7-(8-azabicyclo[3.2.1]octan-3-yl)-3-(7-fluoro-1H-i...) Show SMILES Fc1ccc(-c2c(nn3c(ccnc23)C2CC3CCC(C2)N3)-c2ccncc2)c2cn[nH]c12 |TLB:9:14:21:17.18,(31.91,-31.64,;31.85,-30.1,;30.48,-29.38,;30.43,-27.84,;31.72,-27.02,;31.66,-25.48,;32.57,-24.24,;31.66,-22.98,;30.18,-23.46,;28.85,-22.7,;27.52,-23.47,;27.52,-25.01,;28.85,-25.78,;30.18,-25.01,;28.84,-21.16,;28.4,-19.97,;26.81,-19.06,;25.29,-19.74,;26.66,-19.7,;27.85,-18.84,;29.39,-19.69,;27.34,-17.59,;34.1,-24.23,;34.87,-25.57,;36.41,-25.57,;37.18,-24.23,;36.4,-22.9,;34.86,-22.9,;33.09,-27.73,;34.54,-27.19,;35.5,-28.4,;34.65,-29.69,;33.16,-29.28,)| Show InChI InChI=1S/C25H22FN7/c26-20-4-3-18(19-13-29-31-24(19)20)22-23(14-5-8-27-9-6-14)32-33-21(7-10-28-25(22)33)15-11-16-1-2-17(12-15)30-16/h3-10,13,15-17,30H,1-2,11-12H2,(H,29,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.80	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of B-Raf				Bioorg Med Chem Lett 19: 6957-61 (2009) Article DOI: 10.1016/j.bmcl.2009.10.058 BindingDB Entry DOI: 10.7270/Q2833S34
					More data for this Ligand-Target Pair