BDBM50303274 CHEMBL577742::N1-(4-(2-(1-ethyl-1H-imidazole-4-carbonyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-N3-(2-(trifluoromethyl)phenyl)malonamide

SMILES: CCn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)CC(=O)Nc4ccccc4C(F)(F)F)cc3F)c2s1

InChI Key: InChIKey=XHYQGPMEHCDPLG-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50303274   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50303274 (CHEMBL577742 | N1-(4-(2-(1-ethyl-1H-imidazole-4-ca...) Show SMILES CCn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)CC(=O)Nc4ccccc4C(F)(F)F)cc3F)c2s1 Show InChI InChI=1S/C28H21F4N5O3S/c1-2-37-14-21(34-15-37)24-12-20-27(41-24)23(9-10-33-20)40-22-8-7-16(11-18(22)29)35-25(38)13-26(39)36-19-6-4-3-5-17(19)28(30,31)32/h3-12,14-15H,2,13H2,1H3,(H,35,38)(H,36,39)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc. Curated by ChEMBL					Assay Description Inhibition of GST-fused recombinant VEGFR2 expressed in baculovirus infected Sf9 cells after 10 mins by DELFIA assay				Bioorg Med Chem Lett 19: 6836-9 (2009) Article DOI: 10.1016/j.bmcl.2009.10.095 BindingDB Entry DOI: 10.7270/Q2GM87C1
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50303274 (CHEMBL577742 | N1-(4-(2-(1-ethyl-1H-imidazole-4-ca...) Show SMILES CCn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)CC(=O)Nc4ccccc4C(F)(F)F)cc3F)c2s1 Show InChI InChI=1S/C28H21F4N5O3S/c1-2-37-14-21(34-15-37)24-12-20-27(41-24)23(9-10-33-20)40-22-8-7-16(11-18(22)29)35-25(38)13-26(39)36-19-6-4-3-5-17(19)28(30,31)32/h3-12,14-15H,2,13H2,1H3,(H,35,38)(H,36,39)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc. Curated by ChEMBL					Assay Description Inhibition of TPR-met autophosphorylation expressed in HEK293T cells after 150 mins by ELISA				Bioorg Med Chem Lett 19: 6836-9 (2009) Article DOI: 10.1016/j.bmcl.2009.10.095 BindingDB Entry DOI: 10.7270/Q2GM87C1
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50303274 (CHEMBL577742 | N1-(4-(2-(1-ethyl-1H-imidazole-4-ca...) Show SMILES CCn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)CC(=O)Nc4ccccc4C(F)(F)F)cc3F)c2s1 Show InChI InChI=1S/C28H21F4N5O3S/c1-2-37-14-21(34-15-37)24-12-20-27(41-24)23(9-10-33-20)40-22-8-7-16(11-18(22)29)35-25(38)13-26(39)36-19-6-4-3-5-17(19)28(30,31)32/h3-12,14-15H,2,13H2,1H3,(H,35,38)(H,36,39)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	91	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc. Curated by ChEMBL					Assay Description Inhibition of GST-fused recombinant C-met expressed in baculovirus infected high five cells after 30 mins by DELFIA assay				Bioorg Med Chem Lett 19: 6836-9 (2009) Article DOI: 10.1016/j.bmcl.2009.10.095 BindingDB Entry DOI: 10.7270/Q2GM87C1
					More data for this Ligand-Target Pair