null

SMILES: CCn1ncc2c(nc(nc12)-c1ccc(NC(=O)Nc2ccc(CN)cc2)cc1)N1CC2CCC(C1)O2

InChI Key: InChIKey=ODSKIIXTBSXLGG-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50303295   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50303295 (1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-et...) Show SMILES CCn1ncc2c(nc(nc12)-c1ccc(NC(=O)Nc2ccc(CN)cc2)cc1)N1CC2CCC(C1)O2 |TLB:6:29:36:32.33| Show InChI InChI=1S/C27H30N8O2/c1-2-35-26-23(14-29-35)25(34-15-21-11-12-22(16-34)37-21)32-24(33-26)18-5-9-20(10-6-18)31-27(36)30-19-7-3-17(13-28)4-8-19/h3-10,14,21-22H,2,11-13,15-16,28H2,1H3,(H2,30,31,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Binding affinity to PI3Kalpha by fluorescence polarization assay				Bioorg Med Chem Lett 19: 6830-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.096 BindingDB Entry DOI: 10.7270/Q2BV7GPR
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50303295 (1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-et...) Show SMILES CCn1ncc2c(nc(nc12)-c1ccc(NC(=O)Nc2ccc(CN)cc2)cc1)N1CC2CCC(C1)O2 |TLB:6:29:36:32.33| Show InChI InChI=1S/C27H30N8O2/c1-2-35-26-23(14-29-35)25(34-15-21-11-12-22(16-34)37-21)32-24(33-26)18-5-9-20(10-6-18)31-27(36)30-19-7-3-17(13-28)4-8-19/h3-10,14,21-22H,2,11-13,15-16,28H2,1H3,(H2,30,31,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of human Flag-tagged mTOR expressed in HEK293 cells after 2 hrs by DELFIA				Bioorg Med Chem Lett 19: 6830-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.096 BindingDB Entry DOI: 10.7270/Q2BV7GPR
					More data for this Ligand-Target Pair