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BDBM50303669 CHEMBL567266::Naphthalene-2-carboxylic acid{4-[(E)-3-(4,5-dichloro-thiophene-2-sulfonylamino)-3-oxopropenyl]-1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl}-amide

SMILES: CN1C(=O)C(NC(=O)c2ccc3ccccc3c2)c2c1cccc2\C=C\C(=O)NS(=O)(=O)c1cc(Cl)c(Cl)s1

InChI Key: InChIKey=LEOYZGDFRWUAOZ-VAWYXSNFSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50303669   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50303669
PNG
(CHEMBL567266 | Naphthalene-2-carboxylic acid{4-[(E...)
Show SMILES CN1C(=O)C(NC(=O)c2ccc3ccccc3c2)c2c1cccc2\C=C\C(=O)NS(=O)(=O)c1cc(Cl)c(Cl)s1
Show InChI InChI=1S/C27H19Cl2N3O5S2/c1-32-20-8-4-7-16(11-12-21(33)31-39(36,37)22-14-19(28)25(29)38-22)23(20)24(27(32)35)30-26(34)18-10-9-15-5-2-3-6-17(15)13-18/h2-14,24H,1H3,(H,30,34)(H,31,33)/b12-11+
PDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 14.6n/an/an/an/an/an/a



deCODE Chemistry, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human EP3 receptor after 1 hr by liquid scintillation counting


J Med Chem 53: 18-36 (2010)


Article DOI: 10.1021/jm9005912
BindingDB Entry DOI: 10.7270/Q2XP752H
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50303669
PNG
(CHEMBL567266 | Naphthalene-2-carboxylic acid{4-[(E...)
Show SMILES CN1C(=O)C(NC(=O)c2ccc3ccccc3c2)c2c1cccc2\C=C\C(=O)NS(=O)(=O)c1cc(Cl)c(Cl)s1
Show InChI InChI=1S/C27H19Cl2N3O5S2/c1-32-20-8-4-7-16(11-12-21(33)31-39(36,37)22-14-19(28)25(29)38-22)23(20)24(27(32)35)30-26(34)18-10-9-15-5-2-3-6-17(15)13-18/h2-14,24H,1H3,(H,30,34)(H,31,33)/b12-11+
PDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.25E+3n/an/an/an/an/an/a



deCODE Chemistry, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human EP3 receptor after 1 hr by liquid scintillation counting in presence of 10% human serum


J Med Chem 53: 18-36 (2010)


Article DOI: 10.1021/jm9005912
BindingDB Entry DOI: 10.7270/Q2XP752H
More data for this
Ligand-Target Pair