BDBM50303695 CHEMBL585581::Thiophene-2-sulfonic Acid{(E)-3-[1-(2,4-Dichlorobenzyl)-1Hindol-7-y l]acryloyl}amide

SMILES: Clc1ccc(Cn2ccc3cccc(\C=C\C(=O)NS(=O)(=O)c4cccs4)c23)c(Cl)c1

InChI Key: InChIKey=UQEWWXSQAINMCT-VQHVLOKHSA-N

Data: 7 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50303695   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prostanoid EP3 Receptor (Mus musculus (Mouse))	BDBM50303695 (CHEMBL585581 | Thiophene-2-sulfonic Acid{(E)-3-[1-...) Show SMILES Clc1ccc(Cn2ccc3cccc(\C=C\C(=O)NS(=O)(=O)c4cccs4)c23)c(Cl)c1 Show InChI InChI=1S/C22H16Cl2N2O3S2/c23-18-8-6-17(19(24)13-18)14-26-11-10-16-4-1-3-15(22(16)26)7-9-20(27)25-31(28,29)21-5-2-12-30-21/h1-13H,14H2,(H,25,27)/b9-7+	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
deCODE Chemistry, Inc. Curated by ChEMBL					Assay Description Displacement of [3H]PGE2 from mouse EP3 receptor after 1 hr by liquid scintillation counting				J Med Chem 53: 18-36 (2010) Article DOI: 10.1021/jm9005912 BindingDB Entry DOI: 10.7270/Q2XP752H
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50303695 (CHEMBL585581 | Thiophene-2-sulfonic Acid{(E)-3-[1-...) Show SMILES Clc1ccc(Cn2ccc3cccc(\C=C\C(=O)NS(=O)(=O)c4cccs4)c23)c(Cl)c1 Show InChI InChI=1S/C22H16Cl2N2O3S2/c23-18-8-6-17(19(24)13-18)14-26-11-10-16-4-1-3-15(22(16)26)7-9-20(27)25-31(28,29)21-5-2-12-30-21/h1-13H,14H2,(H,25,27)/b9-7+	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.18E+3	n/a	n/a	n/a	n/a	n/a	n/a
deCODE Chemistry, Inc. Curated by ChEMBL					Assay Description Displacement of [3H]PGE2 from human EP4 receptor after 1 hr by liquid scintillation counting				J Med Chem 53: 18-36 (2010) Article DOI: 10.1021/jm9005912 BindingDB Entry DOI: 10.7270/Q2XP752H
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (Homo sapiens (Human))	BDBM50303695 (CHEMBL585581 | Thiophene-2-sulfonic Acid{(E)-3-[1-...) Show SMILES Clc1ccc(Cn2ccc3cccc(\C=C\C(=O)NS(=O)(=O)c4cccs4)c23)c(Cl)c1 Show InChI InChI=1S/C22H16Cl2N2O3S2/c23-18-8-6-17(19(24)13-18)14-26-11-10-16-4-1-3-15(22(16)26)7-9-20(27)25-31(28,29)21-5-2-12-30-21/h1-13H,14H2,(H,25,27)/b9-7+	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
deCODE Chemistry, Inc. Curated by ChEMBL					Assay Description Displacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation counting				J Med Chem 53: 18-36 (2010) Article DOI: 10.1021/jm9005912 BindingDB Entry DOI: 10.7270/Q2XP752H
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor (Homo sapiens (Human))	BDBM50303695 (CHEMBL585581 | Thiophene-2-sulfonic Acid{(E)-3-[1-...) Show SMILES Clc1ccc(Cn2ccc3cccc(\C=C\C(=O)NS(=O)(=O)c4cccs4)c23)c(Cl)c1 Show InChI InChI=1S/C22H16Cl2N2O3S2/c23-18-8-6-17(19(24)13-18)14-26-11-10-16-4-1-3-15(22(16)26)7-9-20(27)25-31(28,29)21-5-2-12-30-21/h1-13H,14H2,(H,25,27)/b9-7+	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
deCODE Chemistry, Inc. Curated by ChEMBL					Assay Description Displacement of [3H]PGE2 from human EP3 receptor after 1 hr by liquid scintillation counting				J Med Chem 53: 18-36 (2010) Article DOI: 10.1021/jm9005912 BindingDB Entry DOI: 10.7270/Q2XP752H
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor (Homo sapiens (Human))	BDBM50303695 (CHEMBL585581 | Thiophene-2-sulfonic Acid{(E)-3-[1-...) Show SMILES Clc1ccc(Cn2ccc3cccc(\C=C\C(=O)NS(=O)(=O)c4cccs4)c23)c(Cl)c1 Show InChI InChI=1S/C22H16Cl2N2O3S2/c23-18-8-6-17(19(24)13-18)14-26-11-10-16-4-1-3-15(22(16)26)7-9-20(27)25-31(28,29)21-5-2-12-30-21/h1-13H,14H2,(H,25,27)/b9-7+	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
deCODE Chemistry, Inc. Curated by ChEMBL					Assay Description Displacement of [3H]PGE2 from human EP3 receptor after 60 mins repeated washing by liquid scintillation counting				J Med Chem 53: 18-36 (2010) Article DOI: 10.1021/jm9005912 BindingDB Entry DOI: 10.7270/Q2XP752H
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor (Homo sapiens (Human))	BDBM50303695 (CHEMBL585581 | Thiophene-2-sulfonic Acid{(E)-3-[1-...) Show SMILES Clc1ccc(Cn2ccc3cccc(\C=C\C(=O)NS(=O)(=O)c4cccs4)c23)c(Cl)c1 Show InChI InChI=1S/C22H16Cl2N2O3S2/c23-18-8-6-17(19(24)13-18)14-26-11-10-16-4-1-3-15(22(16)26)7-9-20(27)25-31(28,29)21-5-2-12-30-21/h1-13H,14H2,(H,25,27)/b9-7+	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	357	n/a	n/a	n/a	n/a	n/a	n/a
deCODE Chemistry, Inc. Curated by ChEMBL					Assay Description Displacement of [3H]PGE2 from human EP3 receptor after 1 hr by liquid scintillation counting in presence of 10% human serum				J Med Chem 53: 18-36 (2010) Article DOI: 10.1021/jm9005912 BindingDB Entry DOI: 10.7270/Q2XP752H
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (EP1) (Homo sapiens (Human))	BDBM50303695 (CHEMBL585581 | Thiophene-2-sulfonic Acid{(E)-3-[1-...) Show SMILES Clc1ccc(Cn2ccc3cccc(\C=C\C(=O)NS(=O)(=O)c4cccs4)c23)c(Cl)c1 Show InChI InChI=1S/C22H16Cl2N2O3S2/c23-18-8-6-17(19(24)13-18)14-26-11-10-16-4-1-3-15(22(16)26)7-9-20(27)25-31(28,29)21-5-2-12-30-21/h1-13H,14H2,(H,25,27)/b9-7+	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
deCODE Chemistry, Inc. Curated by ChEMBL					Assay Description Displacement of [3H]PGE2 from human EP1 receptor after 1 hr by liquid scintillation counting				J Med Chem 53: 18-36 (2010) Article DOI: 10.1021/jm9005912 BindingDB Entry DOI: 10.7270/Q2XP752H
					More data for this Ligand-Target Pair