BDBM50303833 1-(1-(4-Fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo-[1,5-b]isoquinolin-6-yl)but-3-en-1-ol::CHEMBL566391

SMILES: CC12Cn3cnc(c3C=C1CCCC2C(O)CC=C)-c1ccc(F)cc1

InChI Key: InChIKey=HJWUJOGTYFVHKR-UHFFFAOYSA-N

Data: 2 KI  4 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50303833   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50303833 (1-(1-(4-Fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexah...) Show SMILES CC12Cn3cnc(c3C=C1CCCC2C(O)CC=C)-c1ccc(F)cc1 |c:9| Show InChI InChI=1S/C22H25FN2O/c1-3-5-20(26)18-7-4-6-16-12-19-21(15-8-10-17(23)11-9-15)24-14-25(19)13-22(16,18)2/h3,8-12,14,18,20,26H,1,4-7,13H2,2H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Displacement of GS-red from human glucocorticoid receptor by fluorescent polarization assay				J Med Chem 53: 1270-80 (2010) Article DOI: 10.1021/jm901551w BindingDB Entry DOI: 10.7270/Q2KS6SGW
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50303833 (1-(1-(4-Fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexah...) Show SMILES CC12Cn3cnc(c3C=C1CCCC2C(O)CC=C)-c1ccc(F)cc1 |c:9| Show InChI InChI=1S/C22H25FN2O/c1-3-5-20(26)18-7-4-6-16-12-19-21(15-8-10-17(23)11-9-15)24-14-25(19)13-22(16,18)2/h3,8-12,14,18,20,26H,1,4-7,13H2,2H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Displacement of GS-red from human glucocorticoid receptor by fluorescent polarization assay				J Med Chem 53: 1270-80 (2010) Article DOI: 10.1021/jm901551w BindingDB Entry DOI: 10.7270/Q2KS6SGW
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50303833 (1-(1-(4-Fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexah...) Show SMILES CC12Cn3cnc(c3C=C1CCCC2C(O)CC=C)-c1ccc(F)cc1 |c:9| Show InChI InChI=1S/C22H25FN2O/c1-3-5-20(26)18-7-4-6-16-12-19-21(15-8-10-17(23)11-9-15)24-14-25(19)13-22(16,18)2/h3,8-12,14,18,20,26H,1,4-7,13H2,2H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Transrepression activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of IL-1-beta-induced NF-kappaB dependent E-s...				J Med Chem 53: 1270-80 (2010) Article DOI: 10.1021/jm901551w BindingDB Entry DOI: 10.7270/Q2KS6SGW
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50303833 (1-(1-(4-Fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexah...) Show SMILES CC12Cn3cnc(c3C=C1CCCC2C(O)CC=C)-c1ccc(F)cc1 |c:9| Show InChI InChI=1S/C22H25FN2O/c1-3-5-20(26)18-7-4-6-16-12-19-21(15-8-10-17(23)11-9-15)24-14-25(19)13-22(16,18)2/h3,8-12,14,18,20,26H,1,4-7,13H2,2H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>2.50E+3	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Transrepression activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of PMA-induced AP1 activity after 6 hrs by l...				J Med Chem 53: 1270-80 (2010) Article DOI: 10.1021/jm901551w BindingDB Entry DOI: 10.7270/Q2KS6SGW
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50303833 (1-(1-(4-Fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexah...) Show SMILES CC12Cn3cnc(c3C=C1CCCC2C(O)CC=C)-c1ccc(F)cc1 |c:9| Show InChI InChI=1S/C22H25FN2O/c1-3-5-20(26)18-7-4-6-16-12-19-21(15-8-10-17(23)11-9-15)24-14-25(19)13-22(16,18)2/h3,8-12,14,18,20,26H,1,4-7,13H2,2H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>2.50E+3	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Transrepression activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of PMA-induced AP1 activity after 6 hrs by l...				J Med Chem 53: 1270-80 (2010) Article DOI: 10.1021/jm901551w BindingDB Entry DOI: 10.7270/Q2KS6SGW
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50303833 (1-(1-(4-Fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexah...) Show SMILES CC12Cn3cnc(c3C=C1CCCC2C(O)CC=C)-c1ccc(F)cc1 |c:9| Show InChI InChI=1S/C22H25FN2O/c1-3-5-20(26)18-7-4-6-16-12-19-21(15-8-10-17(23)11-9-15)24-14-25(19)13-22(16,18)2/h3,8-12,14,18,20,26H,1,4-7,13H2,2H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Transrepression activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of IL-1-beta-induced NF-kappaB dependent E-s...				J Med Chem 53: 1270-80 (2010) Article DOI: 10.1021/jm901551w BindingDB Entry DOI: 10.7270/Q2KS6SGW
					More data for this Ligand-Target Pair