BDBM50304357 4-(4-ethylphenoxy)-butyric acid 6-oxo-6H-benzo[c]chromen-3-yl ester::CHEMBL595128
SMILES: CCc1ccc(OCCCC(O)Oc2ccc3c(c2)oc(=O)c2ccccc32)cc1
InChI Key: InChIKey=ZRVNMEZPZXJOIW-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
NAD-dependent deacetylase HST2 (Saccharomyces cerevisiae) | BDBM50304357 (4-(4-ethylphenoxy)-butyric acid 6-oxo-6H-benzo[c]c...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem | Article PubMed | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute Curated by ChEMBL | Assay Description Noncompetitive inhibition of yeast Hst2 using NAD+ substrate | Bioorg Med Chem 17: 7031-41 (2009) Article DOI: 10.1016/j.bmc.2009.07.073 BindingDB Entry DOI: 10.7270/Q21V5FWG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD-dependent deacetylase HST2 (Saccharomyces cerevisiae) | BDBM50304357 (4-(4-ethylphenoxy)-butyric acid 6-oxo-6H-benzo[c]c...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem | Article PubMed | 6.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute Curated by ChEMBL | Assay Description Noncompetitive inhibition of yeast Hst2 using Acetyl-lysine substrate | Bioorg Med Chem 17: 7031-41 (2009) Article DOI: 10.1016/j.bmc.2009.07.073 BindingDB Entry DOI: 10.7270/Q21V5FWG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD-dependent deacetylase HST2 (Saccharomyces cerevisiae) | BDBM50304357 (4-(4-ethylphenoxy)-butyric acid 6-oxo-6H-benzo[c]c...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute Curated by ChEMBL | Assay Description Inhibition of yeast Hst2 by fluorimetric assay | Bioorg Med Chem 17: 7031-41 (2009) Article DOI: 10.1016/j.bmc.2009.07.073 BindingDB Entry DOI: 10.7270/Q21V5FWG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD-Dependent Deacetylase Sirtuin-1 (Homo sapiens (Human)) | BDBM50304357 (4-(4-ethylphenoxy)-butyric acid 6-oxo-6H-benzo[c]c...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute Curated by ChEMBL | Assay Description Inhibition of human full length SIRT1 expressed in DE3 cells by fluorimetric assay | Bioorg Med Chem 17: 7031-41 (2009) Article DOI: 10.1016/j.bmc.2009.07.073 BindingDB Entry DOI: 10.7270/Q21V5FWG | |||||||||||
More data for this Ligand-Target Pair |