BDBM50304370 CHEMBL593946::N-(4-(N-1,3,4-thiadiazol-2-ylsulfamoyl)phenyl)acetamide::US9320734, 102

SMILES: CC(=O)Nc1ccc(cc1)S(=O)(=O)Nc1nncs1

InChI Key: InChIKey=TZYCCDLCJHIAHL-UHFFFAOYSA-N

Data: 2 KI  2 IC50  1 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50304370   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAC-alpha serine/threonine-protein kinase [1-123] (Homo sapiens (Human))	BDBM50304370 (CHEMBL593946 | N-(4-(N-1,3,4-thiadiazol-2-ylsulfam...) Show SMILES CC(=O)Nc1ccc(cc1)S(=O)(=O)Nc1nncs1 Show InChI InChI=1S/C10H10N4O3S2/c1-7(15)12-8-2-4-9(5-3-8)19(16,17)14-10-13-11-6-18-10/h2-6H,1H3,(H,12,15)(H,13,14)	PDB GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System; Arizona Board of Regents on behalf of the University of Arizona US Patent					Assay Description SPR interaction analyses were performed with a Biacore 2000, using Biacore 2000 Control Software v3.2 and BIAevaluation v4.1 analysis software (Biaco...				US Patent US9320734 (2016) BindingDB Entry DOI: 10.7270/Q2QF8RRM
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Mus musculus)	BDBM50304370 (CHEMBL593946 | N-(4-(N-1,3,4-thiadiazol-2-ylsulfam...) Show SMILES CC(=O)Nc1ccc(cc1)S(=O)(=O)Nc1nncs1 Show InChI InChI=1S/C10H10N4O3S2/c1-7(15)12-8-2-4-9(5-3-8)19(16,17)14-10-13-11-6-18-10/h2-6H,1H3,(H,12,15)(H,13,14)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of Arizona Curated by ChEMBL					Assay Description Displacement of biotinylated phosphatidylinositol-3,4,5-phosphate from mouse AKT1 PH domain by surface plasmon resonance competitive binding assay				Bioorg Med Chem 19: 2046-54 (2011) Article DOI: 10.1016/j.bmc.2011.01.049 BindingDB Entry DOI: 10.7270/Q2TQ61TR
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50304370 (CHEMBL593946 | N-(4-(N-1,3,4-thiadiazol-2-ylsulfam...) Show SMILES CC(=O)Nc1ccc(cc1)S(=O)(=O)Nc1nncs1 Show InChI InChI=1S/C10H10N4O3S2/c1-7(15)12-8-2-4-9(5-3-8)19(16,17)14-10-13-11-6-18-10/h2-6H,1H3,(H,12,15)(H,13,14)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas Curated by ChEMBL					Assay Description Inhibition of Akt phosphorylation in human BxPC3 cells by Western blotting				Bioorg Med Chem 17: 6983-92 (2009) Article DOI: 10.1016/j.bmc.2009.08.022 BindingDB Entry DOI: 10.7270/Q2513Z8T
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase [1-123] (Homo sapiens (Human))	BDBM50304370 (CHEMBL593946 | N-(4-(N-1,3,4-thiadiazol-2-ylsulfam...) Show SMILES CC(=O)Nc1ccc(cc1)S(=O)(=O)Nc1nncs1 Show InChI InChI=1S/C10H10N4O3S2/c1-7(15)12-8-2-4-9(5-3-8)19(16,17)14-10-13-11-6-18-10/h2-6H,1H3,(H,12,15)(H,13,14)	PDB GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	n/a	1.02E+4	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System; Arizona Board of Regents on behalf of the University of Arizona US Patent					Assay Description SPR interaction analyses were performed with a Biacore 2000, using Biacore 2000 Control Software v3.2 and BIAevaluation v4.1 analysis software (Biaco...				US Patent US9320734 (2016) BindingDB Entry DOI: 10.7270/Q2QF8RRM
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase [1-123] (Homo sapiens (Human))	BDBM50304370 (CHEMBL593946 | N-(4-(N-1,3,4-thiadiazol-2-ylsulfam...) Show SMILES CC(=O)Nc1ccc(cc1)S(=O)(=O)Nc1nncs1 Show InChI InChI=1S/C10H10N4O3S2/c1-7(15)12-8-2-4-9(5-3-8)19(16,17)14-10-13-11-6-18-10/h2-6H,1H3,(H,12,15)(H,13,14)	PDB GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System; Arizona Board of Regents on behalf of the University of Arizona US Patent					Assay Description Inhibition of AKT was measured by Western blots using specific antibodies against phospho-Ser473-AKT in HT-29 lung cancer cells. Inhibition of the ph...				US Patent US9320734 (2016) BindingDB Entry DOI: 10.7270/Q2QF8RRM
					More data for this Ligand-Target Pair