BDBM50304411 CHEMBL594109::cis-2-{4-[(1H-Imidazol-1-yl)methyl]benzyl}-4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one

SMILES: COc1ccc(cc1OC)C1=NN(Cc2ccc(Cn3ccnc3)cc2)C(=O)[C@@H]2CC=CC[C@H]12

InChI Key: InChIKey=QTASPQPKKWVMSC-XZOQPEGZSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50304411   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50304411 (CHEMBL594109 | cis-2-{4-[(1H-Imidazol-1-yl)methyl]...) Show SMILES COc1ccc(cc1OC)C1=NN(Cc2ccc(Cn3ccnc3)cc2)C(=O)[C@@H]2CC=CC[C@H]12 |r,c:33,t:11| Show InChI InChI=1S/C27H28N4O3/c1-33-24-12-11-21(15-25(24)34-2)26-22-5-3-4-6-23(22)27(32)31(29-26)17-20-9-7-19(8-10-20)16-30-14-13-28-18-30/h3-4,7-15,18,22-23H,5-6,16-17H2,1-2H3/t22-,23+/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Kyoto 601-8550 Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4D catalytic domain cloned from human HL60 cells assessed as inhibition of cAMP hydrolysis				Bioorg Med Chem 17: 6959-70 (2009) Article DOI: 10.1016/j.bmc.2009.08.014 BindingDB Entry DOI: 10.7270/Q2WH2Q26
					More data for this Ligand-Target Pair