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BDBM50304509 CHEMBL608717::N4-(4-Methoxybenzyl)-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine

SMILES: COc1ccc(CNc2cc(nc(N)n2)N2CCN(C)CC2)cc1

InChI Key: InChIKey=LAXVFXWUGSEDSP-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50304509   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histamine H4 receptor


(Homo sapiens (Human))		BDBM50304509
PNG
(CHEMBL608717 | N4-(4-Methoxybenzyl)-6-(4-methylpip...)
Show SMILES COc1ccc(CNc2cc(nc(N)n2)N2CCN(C)CC2)cc1
Show InChI InChI=1S/C17H24N6O/c1-22-7-9-23(10-8-22)16-11-15(20-17(18)21-16)19-12-13-3-5-14(24-2)6-4-13/h3-6,11H,7-10,12H2,1-2H3,(H3,18,19,20,21)
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Article
PubMed
 542n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2

Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair