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BDBM50304519 6-(4-Methylpiperazin-1-yl)-N4-(4-(trifluoromethyl)benzyl)pyrimidine-2,4-diamine::CHEMBL612131

SMILES: CN1CCN(CC1)c1cc(NCc2ccc(cc2)C(F)(F)F)nc(N)n1

InChI Key: InChIKey=NVAYBWFJYZUMHO-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50304519   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histamine H4 receptor


(Homo sapiens (Human))		BDBM50304519
PNG
(6-(4-Methylpiperazin-1-yl)-N4-(4-(trifluoromethyl)...)
Show SMILES CN1CCN(CC1)c1cc(NCc2ccc(cc2)C(F)(F)F)nc(N)n1
Show InChI InChI=1S/C17H21F3N6/c1-25-6-8-26(9-7-25)15-10-14(23-16(21)24-15)22-11-12-2-4-13(5-3-12)17(18,19)20/h2-5,10H,6-9,11H2,1H3,(H3,21,22,23,24)
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Article
PubMed
 1.20E+3n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2

Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair