BDBM50304782 CHEMBL609583::N-hydroxy-2-(4-(naphthalen-2-ylsulfonyl)piperazin-1-yl)pyrimidine-5-carboxamide

SMILES: ONC(=O)c1cnc(nc1)N1CCN(CC1)S(=O)(=O)c1ccc2ccccc2c1

InChI Key: InChIKey=MUTBJZVSRNUIHA-UHFFFAOYSA-N

Data: 12 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50304782   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone deacetylase 5 (Homo sapiens (Human))	BDBM50304782 (CHEMBL609583 | N-hydroxy-2-(4-(naphthalen-2-ylsulf...) Show SMILES ONC(=O)c1cnc(nc1)N1CCN(CC1)S(=O)(=O)c1ccc2ccccc2c1 Show InChI InChI=1S/C19H19N5O4S/c25-18(22-26)16-12-20-19(21-13-16)23-7-9-24(10-8-23)29(27,28)17-6-5-14-3-1-2-4-15(14)11-17/h1-6,11-13,26H,7-10H2,(H,22,25)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	7.10	n/a	n/a	n/a	n/a	n/a	n/a
Ortho-Biotech Oncology Research& Development Curated by ChEMBL					Assay Description Inhibition of human HDAC5				Bioorg Med Chem Lett 20: 294-8 (2010) Article DOI: 10.1016/j.bmcl.2009.10.118 BindingDB Entry DOI: 10.7270/Q2DB81ZS
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Homo sapiens (Human))	BDBM50304782 (CHEMBL609583 | N-hydroxy-2-(4-(naphthalen-2-ylsulf...) Show SMILES ONC(=O)c1cnc(nc1)N1CCN(CC1)S(=O)(=O)c1ccc2ccccc2c1 Show InChI InChI=1S/C19H19N5O4S/c25-18(22-26)16-12-20-19(21-13-16)23-7-9-24(10-8-23)29(27,28)17-6-5-14-3-1-2-4-15(14)11-17/h1-6,11-13,26H,7-10H2,(H,22,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Ortho-Biotech Oncology Research& Development Curated by ChEMBL					Assay Description Inhibition of human HDAC1				Bioorg Med Chem Lett 20: 294-8 (2010) Article DOI: 10.1016/j.bmcl.2009.10.118 BindingDB Entry DOI: 10.7270/Q2DB81ZS
					More data for this Ligand-Target Pair
Histone deacetylase 2 (Homo sapiens (Human))	BDBM50304782 (CHEMBL609583 | N-hydroxy-2-(4-(naphthalen-2-ylsulf...) Show SMILES ONC(=O)c1cnc(nc1)N1CCN(CC1)S(=O)(=O)c1ccc2ccccc2c1 Show InChI InChI=1S/C19H19N5O4S/c25-18(22-26)16-12-20-19(21-13-16)23-7-9-24(10-8-23)29(27,28)17-6-5-14-3-1-2-4-15(14)11-17/h1-6,11-13,26H,7-10H2,(H,22,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Ortho-Biotech Oncology Research& Development Curated by ChEMBL					Assay Description Inhibition of human HDAC2				Bioorg Med Chem Lett 20: 294-8 (2010) Article DOI: 10.1016/j.bmcl.2009.10.118 BindingDB Entry DOI: 10.7270/Q2DB81ZS
					More data for this Ligand-Target Pair
Histone deacetylase 3 (Homo sapiens (Human))	BDBM50304782 (CHEMBL609583 | N-hydroxy-2-(4-(naphthalen-2-ylsulf...) Show SMILES ONC(=O)c1cnc(nc1)N1CCN(CC1)S(=O)(=O)c1ccc2ccccc2c1 Show InChI InChI=1S/C19H19N5O4S/c25-18(22-26)16-12-20-19(21-13-16)23-7-9-24(10-8-23)29(27,28)17-6-5-14-3-1-2-4-15(14)11-17/h1-6,11-13,26H,7-10H2,(H,22,25)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Ortho-Biotech Oncology Research& Development Curated by ChEMBL					Assay Description Inhibition of human HDAC3				Bioorg Med Chem Lett 20: 294-8 (2010) Article DOI: 10.1016/j.bmcl.2009.10.118 BindingDB Entry DOI: 10.7270/Q2DB81ZS
					More data for this Ligand-Target Pair
Histone deacetylase 8 (Homo sapiens (Human))	BDBM50304782 (CHEMBL609583 | N-hydroxy-2-(4-(naphthalen-2-ylsulf...) Show SMILES ONC(=O)c1cnc(nc1)N1CCN(CC1)S(=O)(=O)c1ccc2ccccc2c1 Show InChI InChI=1S/C19H19N5O4S/c25-18(22-26)16-12-20-19(21-13-16)23-7-9-24(10-8-23)29(27,28)17-6-5-14-3-1-2-4-15(14)11-17/h1-6,11-13,26H,7-10H2,(H,22,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Ortho-Biotech Oncology Research& Development Curated by ChEMBL					Assay Description Inhibition of human HDAC8				Bioorg Med Chem Lett 20: 294-8 (2010) Article DOI: 10.1016/j.bmcl.2009.10.118 BindingDB Entry DOI: 10.7270/Q2DB81ZS
					More data for this Ligand-Target Pair
Histone deacetylase 8 (Homo sapiens (Human))	BDBM50304782 (CHEMBL609583 | N-hydroxy-2-(4-(naphthalen-2-ylsulf...) Show SMILES ONC(=O)c1cnc(nc1)N1CCN(CC1)S(=O)(=O)c1ccc2ccccc2c1 Show InChI InChI=1S/C19H19N5O4S/c25-18(22-26)16-12-20-19(21-13-16)23-7-9-24(10-8-23)29(27,28)17-6-5-14-3-1-2-4-15(14)11-17/h1-6,11-13,26H,7-10H2,(H,22,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Jadavpur University Curated by ChEMBL					Assay Description Inhibition of HDAC8 (unknown origin)				Eur J Med Chem 164: 214-240 (2019)
					More data for this Ligand-Target Pair
Histone deacetylase 7 (Homo sapiens (Human))	BDBM50304782 (CHEMBL609583 | N-hydroxy-2-(4-(naphthalen-2-ylsulf...) Show SMILES ONC(=O)c1cnc(nc1)N1CCN(CC1)S(=O)(=O)c1ccc2ccccc2c1 Show InChI InChI=1S/C19H19N5O4S/c25-18(22-26)16-12-20-19(21-13-16)23-7-9-24(10-8-23)29(27,28)17-6-5-14-3-1-2-4-15(14)11-17/h1-6,11-13,26H,7-10H2,(H,22,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
Ortho-Biotech Oncology Research& Development Curated by ChEMBL					Assay Description Inhibition of human HDAC7				Bioorg Med Chem Lett 20: 294-8 (2010) Article DOI: 10.1016/j.bmcl.2009.10.118 BindingDB Entry DOI: 10.7270/Q2DB81ZS
					More data for this Ligand-Target Pair
Histone deacetylase 9 (Homo sapiens (Human))	BDBM50304782 (CHEMBL609583 | N-hydroxy-2-(4-(naphthalen-2-ylsulf...) Show SMILES ONC(=O)c1cnc(nc1)N1CCN(CC1)S(=O)(=O)c1ccc2ccccc2c1 Show InChI InChI=1S/C19H19N5O4S/c25-18(22-26)16-12-20-19(21-13-16)23-7-9-24(10-8-23)29(27,28)17-6-5-14-3-1-2-4-15(14)11-17/h1-6,11-13,26H,7-10H2,(H,22,25)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Ortho-Biotech Oncology Research& Development Curated by ChEMBL					Assay Description Inhibition of human HDAC9				Bioorg Med Chem Lett 20: 294-8 (2010) Article DOI: 10.1016/j.bmcl.2009.10.118 BindingDB Entry DOI: 10.7270/Q2DB81ZS
					More data for this Ligand-Target Pair
Cereblon/Histone deacetylase 6 (Homo sapiens (Human))	BDBM50304782 (CHEMBL609583 | N-hydroxy-2-(4-(naphthalen-2-ylsulf...) Show SMILES ONC(=O)c1cnc(nc1)N1CCN(CC1)S(=O)(=O)c1ccc2ccccc2c1 Show InChI InChI=1S/C19H19N5O4S/c25-18(22-26)16-12-20-19(21-13-16)23-7-9-24(10-8-23)29(27,28)17-6-5-14-3-1-2-4-15(14)11-17/h1-6,11-13,26H,7-10H2,(H,22,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
Ortho-Biotech Oncology Research& Development Curated by ChEMBL					Assay Description Inhibition of human HDAC6				Bioorg Med Chem Lett 20: 294-8 (2010) Article DOI: 10.1016/j.bmcl.2009.10.118 BindingDB Entry DOI: 10.7270/Q2DB81ZS
					More data for this Ligand-Target Pair
Histone deacetylase 10 (Homo sapiens (Human))	BDBM50304782 (CHEMBL609583 | N-hydroxy-2-(4-(naphthalen-2-ylsulf...) Show SMILES ONC(=O)c1cnc(nc1)N1CCN(CC1)S(=O)(=O)c1ccc2ccccc2c1 Show InChI InChI=1S/C19H19N5O4S/c25-18(22-26)16-12-20-19(21-13-16)23-7-9-24(10-8-23)29(27,28)17-6-5-14-3-1-2-4-15(14)11-17/h1-6,11-13,26H,7-10H2,(H,22,25)	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
Ortho-Biotech Oncology Research& Development Curated by ChEMBL					Assay Description Inhibition of human HDAC10				Bioorg Med Chem Lett 20: 294-8 (2010) Article DOI: 10.1016/j.bmcl.2009.10.118 BindingDB Entry DOI: 10.7270/Q2DB81ZS
					More data for this Ligand-Target Pair
Histone deacetylase 11 (Homo sapiens (Human))	BDBM50304782 (CHEMBL609583 | N-hydroxy-2-(4-(naphthalen-2-ylsulf...) Show SMILES ONC(=O)c1cnc(nc1)N1CCN(CC1)S(=O)(=O)c1ccc2ccccc2c1 Show InChI InChI=1S/C19H19N5O4S/c25-18(22-26)16-12-20-19(21-13-16)23-7-9-24(10-8-23)29(27,28)17-6-5-14-3-1-2-4-15(14)11-17/h1-6,11-13,26H,7-10H2,(H,22,25)	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Ortho-Biotech Oncology Research& Development Curated by ChEMBL					Assay Description Inhibition of human HDAC11				Bioorg Med Chem Lett 20: 294-8 (2010) Article DOI: 10.1016/j.bmcl.2009.10.118 BindingDB Entry DOI: 10.7270/Q2DB81ZS
					More data for this Ligand-Target Pair
Histone deacetylase 4 (Homo sapiens (Human))	BDBM50304782 (CHEMBL609583 | N-hydroxy-2-(4-(naphthalen-2-ylsulf...) Show SMILES ONC(=O)c1cnc(nc1)N1CCN(CC1)S(=O)(=O)c1ccc2ccccc2c1 Show InChI InChI=1S/C19H19N5O4S/c25-18(22-26)16-12-20-19(21-13-16)23-7-9-24(10-8-23)29(27,28)17-6-5-14-3-1-2-4-15(14)11-17/h1-6,11-13,26H,7-10H2,(H,22,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	n/a
Ortho-Biotech Oncology Research& Development Curated by ChEMBL					Assay Description Inhibition of human HDAC4				Bioorg Med Chem Lett 20: 294-8 (2010) Article DOI: 10.1016/j.bmcl.2009.10.118 BindingDB Entry DOI: 10.7270/Q2DB81ZS
					More data for this Ligand-Target Pair