null
SMILES: C1CN(CCN1)c1ncnc2[nH]ccc12
InChI Key: InChIKey=LZSXQBNNRGZPES-UHFFFAOYSA-N
PDB links: 4 PDB IDs match this monomer.
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
5-hydroxytryptamine receptor 2C (Homo sapiens (Human)) | BDBM50304819 (4-(piperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine | C...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 755 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HT | Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human)) | BDBM50304819 (4-(piperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine | C...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | US Patent | 1.05E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sapienza Universitāadi Roma | Assay Description The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel... | J Med Chem 51: 1560-76 (2008) BindingDB Entry DOI: 10.7270/Q2HX1FZW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM50304819 (4-(piperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine | C...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | US Patent | 1.05E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sapienza Universitāadi Roma | Assay Description The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel... | J Med Chem 51: 1560-76 (2008) BindingDB Entry DOI: 10.7270/Q2HX1FZW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2C (Homo sapiens (Human)) | BDBM50304819 (4-(piperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine | C...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 755 | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Agonist activity against human 5HT2C receptor by FLIPR assay | Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M | |||||||||||
More data for this Ligand-Target Pair |