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SMILES: Cc1ccc(Nc2ccc(cn2)C(=O)N2CCCCC2)cn1

InChI Key: InChIKey=QRVCWZSQSJQWPT-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50305036   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50305036
PNG
((6-(6-methylpyridin-3-ylamino)pyridin-3-yl)(piperi...)
Show SMILES Cc1ccc(Nc2ccc(cn2)C(=O)N2CCCCC2)cn1
Show InChI InChI=1S/C17H20N4O/c1-13-5-7-15(12-18-13)20-16-8-6-14(11-19-16)17(22)21-9-3-2-4-10-21/h5-8,11-12H,2-4,9-10H2,1H3,(H,19,20)
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Article
PubMed
n/an/a 420n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Antagonist activity at human mGluR5 assessed as inhibition of glutamate-induced elevation of intracellular calcium concentration

Bioorg Med Chem Lett 20: 184-8 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.001
BindingDB Entry DOI: 10.7270/Q2QN66VN
More data for this
Ligand-Target Pair