BDBM50305051 (R)-(5-chloro-6-(6-methylpyridin-3-ylamino)pyridin-3-yl)(2-methylpiperidin-1-yl)methanone::CHEMBL594990
SMILES: C[C@@H]1CCCCN1C(=O)c1cnc(Nc2ccc(C)nc2)c(Cl)c1
InChI Key: InChIKey=QNYQRZYDZSRQND-CYBMUJFWSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50305051 ((R)-(5-chloro-6-(6-methylpyridin-3-ylamino)pyridin...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.40E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research Curated by ChEMBL | Assay Description Antagonist activity at human mGluR5 assessed as inhibition of glutamate-induced elevation of intracellular calcium concentration | Bioorg Med Chem Lett 20: 184-8 (2010) Article DOI: 10.1016/j.bmcl.2009.11.001 BindingDB Entry DOI: 10.7270/Q2QN66VN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50305051 ((R)-(5-chloro-6-(6-methylpyridin-3-ylamino)pyridin...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 430 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research Curated by ChEMBL | Assay Description Antagonist activity at human mGluR5 assessed as inhibition of quisqualate-induced intracellular inositol phosphate accumulation | Bioorg Med Chem Lett 20: 184-8 (2010) Article DOI: 10.1016/j.bmcl.2009.11.001 BindingDB Entry DOI: 10.7270/Q2QN66VN | |||||||||||
More data for this Ligand-Target Pair |