BDBM50305349 (+/-)-2-(2-aminoethoxy)-3-(1-butyl-1H-imidazol-4-yl)propanoic acid::CHEMBL590859
SMILES: CCCCn1cnc(CC(OCCN)C(O)=O)c1
InChI Key: InChIKey=OKKIGEKMWNYVMZ-UHFFFAOYSA-N
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Carboxypeptidase B2 isoform A (Homo sapiens (Human)) | BDBM50305349 ((+/-)-2-(2-aminoethoxy)-3-(1-butyl-1H-imidazol-4-y...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Inhibition of active form of human recombinant TAFI assessed as substrate turnover every 15 seconds for 30 mins | Bioorg Med Chem Lett 20: 92-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.029 BindingDB Entry DOI: 10.7270/Q2J1038R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thrombin-activatable fibrinolysis (TAFI) (Homo sapiens (Human)) | BDBM50305349 ((+/-)-2-(2-aminoethoxy)-3-(1-butyl-1H-imidazol-4-y...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 360 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Inhibition of human pancreatic carboxypeptidase B | Bioorg Med Chem Lett 20: 92-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.029 BindingDB Entry DOI: 10.7270/Q2J1038R | |||||||||||
More data for this Ligand-Target Pair |