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BDBM50305436 2-(1-(2-chlorophenyl)-5-(4-chlorophenyl)-3-(2-(4-fluorophenyl)piperidine-1-carbonyl)-1H-pyrazol-4-yl)acetonitrile::CHEMBL589400

SMILES: Fc1ccc(cc1)C1CCCCN1C(=O)c1nn(c(c1CC#N)-c1ccc(Cl)cc1)-c1ccccc1Cl

InChI Key: InChIKey=DOTRNDAQICTKOW-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50305436   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50305436
PNG
(2-(1-(2-chlorophenyl)-5-(4-chlorophenyl)-3-(2-(4-f...)
Show SMILES Fc1ccc(cc1)C1CCCCN1C(=O)c1nn(c(c1CC#N)-c1ccc(Cl)cc1)-c1ccccc1Cl
Show InChI InChI=1S/C29H23Cl2FN4O/c30-21-12-8-20(9-13-21)28-23(16-17-33)27(34-36(28)26-7-2-1-5-24(26)31)29(37)35-18-4-3-6-25(35)19-10-14-22(32)15-11-19/h1-2,5,7-15,25H,3-4,6,16,18H2
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 23n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP55940-stimulated GTPgammaS binding


Bioorg Med Chem Lett 20: 26-30 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.047
BindingDB Entry DOI: 10.7270/Q28G8KS9
More data for this
Ligand-Target Pair