BDBM50305663 (3-(1-(1-benzylpiperidin-4-yl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenyl)methanol::CHEMBL603848

SMILES: OCc1cccc(c1)-c1nc(N2CCOCC2)c2cnn(C3CCN(Cc4ccccc4)CC3)c2n1

InChI Key: InChIKey=ADGMDJYORUZUNO-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50305663   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50305663 ((3-(1-(1-benzylpiperidin-4-yl)-4-morpholino-1H-pyr...) Show SMILES OCc1cccc(c1)-c1nc(N2CCOCC2)c2cnn(C3CCN(Cc4ccccc4)CC3)c2n1 Show InChI InChI=1S/C28H32N6O2/c35-20-22-7-4-8-23(17-22)26-30-27(33-13-15-36-16-14-33)25-18-29-34(28(25)31-26)24-9-11-32(12-10-24)19-21-5-2-1-3-6-21/h1-8,17-18,24,35H,9-16,19-20H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of GST-GRP1-fused PI3Kalpha by microtiter plate based fluorescence polarization assay				Bioorg Med Chem Lett 20: 636-9 (2010) Article DOI: 10.1016/j.bmcl.2009.11.051 BindingDB Entry DOI: 10.7270/Q2V98852
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50305663 ((3-(1-(1-benzylpiperidin-4-yl)-4-morpholino-1H-pyr...) Show SMILES OCc1cccc(c1)-c1nc(N2CCOCC2)c2cnn(C3CCN(Cc4ccccc4)CC3)c2n1 Show InChI InChI=1S/C28H32N6O2/c35-20-22-7-4-8-23(17-22)26-30-27(33-13-15-36-16-14-33)25-18-29-34(28(25)31-26)24-9-11-32(12-10-24)19-21-5-2-1-3-6-21/h1-8,17-18,24,35H,9-16,19-20H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of human TOR in HEK293 cells by DELFIA				Bioorg Med Chem Lett 20: 636-9 (2010) Article DOI: 10.1016/j.bmcl.2009.11.051 BindingDB Entry DOI: 10.7270/Q2V98852
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM50305663 ((3-(1-(1-benzylpiperidin-4-yl)-4-morpholino-1H-pyr...) Show SMILES OCc1cccc(c1)-c1nc(N2CCOCC2)c2cnn(C3CCN(Cc4ccccc4)CC3)c2n1 Show InChI InChI=1S/C28H32N6O2/c35-20-22-7-4-8-23(17-22)26-30-27(33-13-15-36-16-14-33)25-18-29-34(28(25)31-26)24-9-11-32(12-10-24)19-21-5-2-1-3-6-21/h1-8,17-18,24,35H,9-16,19-20H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	975	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of GST-GRP1-fused PI3Kgamma by microtiter plate based fluorescence polarization assay				Bioorg Med Chem Lett 20: 636-9 (2010) Article DOI: 10.1016/j.bmcl.2009.11.051 BindingDB Entry DOI: 10.7270/Q2V98852
					More data for this Ligand-Target Pair