BDBM50305692 3-tert-butyl-6-(2,4-difluorophenylthio)-[1,2,4]triazolo[4,3-a]pyridine hydrochloride::CHEMBL1198626::CHEMBL609275
SMILES: CC(C)(C)c1nnc2ccc(Sc3ccc(F)cc3F)cn12
InChI Key: InChIKey=QBRGSYLNUUOUBB-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 50305692 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Mitogen-activated protein kinase 13 (MAPK13)
(Homo sapiens (Human)) | BDBM50305692
(3-tert-butyl-6-(2,4-difluorophenylthio)-[1,2,4]tri...)Show InChI InChI=1S/C16H15F2N3S/c1-16(2,3)15-20-19-14-7-5-11(9-21(14)15)22-13-6-4-10(17)8-12(13)18/h4-9H,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Inhibition of p38alpha |
Bioorg Med Chem Lett 22: 3431-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.099 BindingDB Entry DOI: 10.7270/Q2348MNX |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50305692
(3-tert-butyl-6-(2,4-difluorophenylthio)-[1,2,4]tri...)Show InChI InChI=1S/C16H15F2N3S/c1-16(2,3)15-20-19-14-7-5-11(9-21(14)15)22-13-6-4-10(17)8-12(13)18/h4-9H,1-3H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of p38 alpha |
Bioorg Med Chem Lett 20: 469-73 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.114 BindingDB Entry DOI: 10.7270/Q2G160XP |
More data for this Ligand-Target Pair | |