BDBM50305866 5-methyl-6-phenyl-3-(pyridin-3-yl)isoxazolo[4,5-c]pyridin-4(5H)-one::CHEMBL596274

SMILES: Cn1c(cc2onc(-c3cccnc3)c2c1=O)-c1ccccc1

InChI Key: InChIKey=BJYLAOMUPXSMMJ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50305866   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 7 (mGlu7) (Rattus norvegicus (Rat))	BDBM50305866 (5-methyl-6-phenyl-3-(pyridin-3-yl)isoxazolo[4,5-c]...) Show SMILES Cn1c(cc2onc(-c3cccnc3)c2c1=O)-c1ccccc1 Show InChI InChI=1S/C18H13N3O2/c1-21-14(12-6-3-2-4-7-12)10-15-16(18(21)22)17(20-23-15)13-8-5-9-19-11-13/h2-11H,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPR				Bioorg Med Chem Lett 20: 726-9 (2010) Article DOI: 10.1016/j.bmcl.2009.11.070 BindingDB Entry DOI: 10.7270/Q2F18ZSX
					More data for this Ligand-Target Pair