BDBM50305880 (S)-1-(6-(furan-3-yl)-5-(3-methyl-1H-pyrazolo[4,3-b]pyridin-5-yl)pyridin-3-yloxy)-3-(1H-indol-3-yl)propan-2-amine::CHEMBL596073

SMILES: Cc1n[nH]c2ccc(nc12)-c1cc(OC[C@@H](N)Cc2c[nH]c3ccccc23)cnc1-c1ccoc1

InChI Key: InChIKey=RCRPFFUFPBVPHF-IBGZPJMESA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50305880   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50305880 ((S)-1-(6-(furan-3-yl)-5-(3-methyl-1H-pyrazolo[4,3-...) Show SMILES Cc1n[nH]c2ccc(nc12)-c1cc(OC[C@@H](N)Cc2c[nH]c3ccccc23)cnc1-c1ccoc1 |r| Show InChI InChI=1S/C27H24N6O2/c1-16-26-25(33-32-16)7-6-24(31-26)22-11-20(13-30-27(22)17-8-9-34-14-17)35-15-19(28)10-18-12-29-23-5-3-2-4-21(18)23/h2-9,11-14,19,29H,10,15,28H2,1H3,(H,32,33)/t19-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of AKT1				Bioorg Med Chem Lett 20: 679-83 (2010) Article DOI: 10.1016/j.bmcl.2009.11.060 BindingDB Entry DOI: 10.7270/Q298873F
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50305880 ((S)-1-(6-(furan-3-yl)-5-(3-methyl-1H-pyrazolo[4,3-...) Show SMILES Cc1n[nH]c2ccc(nc12)-c1cc(OC[C@@H](N)Cc2c[nH]c3ccccc23)cnc1-c1ccoc1 |r| Show InChI InChI=1S/C27H24N6O2/c1-16-26-25(33-32-16)7-6-24(31-26)22-11-20(13-30-27(22)17-8-9-34-14-17)35-15-19(28)10-18-12-29-23-5-3-2-4-21(18)23/h2-9,11-14,19,29H,10,15,28H2,1H3,(H,32,33)/t19-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of CYP3A4				Bioorg Med Chem Lett 20: 679-83 (2010) Article DOI: 10.1016/j.bmcl.2009.11.060 BindingDB Entry DOI: 10.7270/Q298873F
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50305880 ((S)-1-(6-(furan-3-yl)-5-(3-methyl-1H-pyrazolo[4,3-...) Show SMILES Cc1n[nH]c2ccc(nc12)-c1cc(OC[C@@H](N)Cc2c[nH]c3ccccc23)cnc1-c1ccoc1 |r| Show InChI InChI=1S/C27H24N6O2/c1-16-26-25(33-32-16)7-6-24(31-26)22-11-20(13-30-27(22)17-8-9-34-14-17)35-15-19(28)10-18-12-29-23-5-3-2-4-21(18)23/h2-9,11-14,19,29H,10,15,28H2,1H3,(H,32,33)/t19-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.86E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of GSK3beta phosphorylation in human BT474 cells				Bioorg Med Chem Lett 20: 679-83 (2010) Article DOI: 10.1016/j.bmcl.2009.11.060 BindingDB Entry DOI: 10.7270/Q298873F
					More data for this Ligand-Target Pair