BDBM50305984 5,6-bis(4-chlorophenyl)-N-(4,4-difluorocyclohexyl)-3-(methoxymethyl)pyrazine-2-carbothioamide::CHEMBL605526
SMILES: COCc1nc(-c2ccc(Cl)cc2)c(nc1C(=S)NC1CCC(F)(F)CC1)-c1ccc(Cl)cc1
InChI Key: InChIKey=ZVFXKNSYECSLJW-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM50305984 (5,6-bis(4-chlorophenyl)-N-(4,4-difluorocyclohexyl)...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D M£lndal Curated by ChEMBL | Assay Description Agonist activity at human CB1 receptor assessed as stimulation of [35S]GTPgammaS binding | Bioorg Med Chem Lett 20: 479-82 (2010) Article DOI: 10.1016/j.bmcl.2009.11.125 BindingDB Entry DOI: 10.7270/Q2X34XKB | |||||||||||
More data for this Ligand-Target Pair |