BDBM50306101 (S)-1-(5-(3-methyl-1H-indazol-5-yl)-6-(thiophen-3-yl)pyridin-3-yloxy)-3-phenylpropan-2-amine::CHEMBL604060

SMILES: Cc1n[nH]c2ccc(cc12)-c1cc(OC[C@@H](N)Cc2ccccc2)cnc1-c1ccsc1

InChI Key: InChIKey=VPHOSYHDFSVNET-NRFANRHFSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50306101   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50306101 ((S)-1-(5-(3-methyl-1H-indazol-5-yl)-6-(thiophen-3-...) Show SMILES Cc1n[nH]c2ccc(cc12)-c1cc(OC[C@@H](N)Cc2ccccc2)cnc1-c1ccsc1 |r| Show InChI InChI=1S/C26H24N4OS/c1-17-23-12-19(7-8-25(23)30-29-17)24-13-22(14-28-26(24)20-9-10-32-16-20)31-15-21(27)11-18-5-3-2-4-6-18/h2-10,12-14,16,21H,11,15,27H2,1H3,(H,29,30)/t21-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of full length AKT1				Bioorg Med Chem Lett 20: 673-8 (2010) Article DOI: 10.1016/j.bmcl.2009.11.064 BindingDB Entry DOI: 10.7270/Q2D21XQ0
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM50306101 ((S)-1-(5-(3-methyl-1H-indazol-5-yl)-6-(thiophen-3-...) Show SMILES Cc1n[nH]c2ccc(cc12)-c1cc(OC[C@@H](N)Cc2ccccc2)cnc1-c1ccsc1 |r| Show InChI InChI=1S/C26H24N4OS/c1-17-23-12-19(7-8-25(23)30-29-17)24-13-22(14-28-26(24)20-9-10-32-16-20)31-15-21(27)11-18-5-3-2-4-6-18/h2-10,12-14,16,21H,11,15,27H2,1H3,(H,29,30)/t21-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of ROCK1				Bioorg Med Chem Lett 20: 673-8 (2010) Article DOI: 10.1016/j.bmcl.2009.11.064 BindingDB Entry DOI: 10.7270/Q2D21XQ0
					More data for this Ligand-Target Pair