BDBM50306167 5-fluoro-2-(3-fluoro-4-(1-methylazetidine-3-carboxamido)phenyl)-2H-indazole-7-carboxamide::CHEMBL605929

SMILES: CN1CC(C1)C(=O)Nc1ccc(cc1F)-n1cc2cc(F)cc(C(N)=O)c2n1

InChI Key: InChIKey=NYKJRMYPHXXYDN-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50306167   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM50306167 (5-fluoro-2-(3-fluoro-4-(1-methylazetidine-3-carbox...) Show SMILES CN1CC(C1)C(=O)Nc1ccc(cc1F)-n1cc2cc(F)cc(C(N)=O)c2n1 Show InChI InChI=1S/C19H17F2N5O2/c1-25-7-11(8-25)19(28)23-16-3-2-13(6-15(16)21)26-9-10-4-12(20)5-14(18(22)27)17(10)24-26/h2-6,9,11H,7-8H2,1H3,(H2,22,27)(H,23,28)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
IRBM-Merck Research Laboratories Rome Curated by ChEMBL					Assay Description Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay				Bioorg Med Chem Lett 20: 488-92 (2010) Article DOI: 10.1016/j.bmcl.2009.11.127 BindingDB Entry DOI: 10.7270/Q2W37WFZ
					More data for this Ligand-Target Pair