BDBM50306169 (R)-5-fluoro-2-(3-fluoro-4-(1-methylpiperidine-3-carboxamido)phenyl)-2H-indazole-7-carboxamide::CHEMBL595230

SMILES: CN1CCC[C@H](C1)C(=O)Nc1ccc(cc1F)-n1cc2cc(F)cc(C(N)=O)c2n1

InChI Key: InChIKey=ZEOHIMOPXHSCLJ-GFCCVEGCSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50306169   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM50306169 ((R)-5-fluoro-2-(3-fluoro-4-(1-methylpiperidine-3-c...) Show SMILES CN1CCC[C@H](C1)C(=O)Nc1ccc(cc1F)-n1cc2cc(F)cc(C(N)=O)c2n1 |r| Show InChI InChI=1S/C21H21F2N5O2/c1-27-6-2-3-12(10-27)21(30)25-18-5-4-15(9-17(18)23)28-11-13-7-14(22)8-16(20(24)29)19(13)26-28/h4-5,7-9,11-12H,2-3,6,10H2,1H3,(H2,24,29)(H,25,30)/t12-/m1/s1	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
IRBM-Merck Research Laboratories Rome Curated by ChEMBL					Assay Description Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay				Bioorg Med Chem Lett 20: 488-92 (2010) Article DOI: 10.1016/j.bmcl.2009.11.127 BindingDB Entry DOI: 10.7270/Q2W37WFZ
					More data for this Ligand-Target Pair