BindingDB PrimarySearch

BDBM50306503 4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenylamino)-N-phenylbutanamide::CHEMBL602703

SMILES: Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(CC(=O)Nc4ccccc4)C(F)(F)F)cc3F)c2s1

InChI Key: InChIKey=ZXXJTQRLPRCGMZ-UHFFFAOYSA-N

Data: 8 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50306503
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Macrophage-stimulating protein receptor (Homo sapiens (Human))	BDBM50306503 (4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imid...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.03E+3	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc. Curated by ChEMBL					Assay Description Inhibition of TPR-tagged RON catalytic domain expressed in HEK293 cells				Bioorg Med Chem Lett 20: 2745-9 (2010) Article DOI: 10.1016/j.bmcl.2010.03.073 BindingDB Entry DOI: 10.7270/Q24T6JJ6
MethylGene Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50306503 (4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imid...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc Curated by ChEMBL					Assay Description Inhibition of TPR-fused Met autophosphorylation expressed in HEK293T cells after 150 mins by ELISA				Bioorg Med Chem Lett 20: 848-52 (2010) Article DOI: 10.1016/j.bmcl.2009.12.099 BindingDB Entry DOI: 10.7270/Q2XW4JWR
MethylGene Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50306503 (4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imid...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc Curated by ChEMBL					Assay Description Inhibition of c-MET in human A549 cells by wound healing assay				Bioorg Med Chem Lett 20: 848-52 (2010) Article DOI: 10.1016/j.bmcl.2009.12.099 BindingDB Entry DOI: 10.7270/Q2XW4JWR
MethylGene Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50306503 (4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imid...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc. Curated by ChEMBL					Assay Description Inhibition of VEGFR2				Bioorg Med Chem Lett 20: 2745-9 (2010) Article DOI: 10.1016/j.bmcl.2010.03.073 BindingDB Entry DOI: 10.7270/Q24T6JJ6
MethylGene Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50306503 (4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imid...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc Curated by ChEMBL					Assay Description Inhibition of recombinant GST-fused VEGFR2 expressed in baculovirus infected Sf9 cells by DELFIA				Bioorg Med Chem Lett 20: 848-52 (2010) Article DOI: 10.1016/j.bmcl.2009.12.099 BindingDB Entry DOI: 10.7270/Q2XW4JWR
MethylGene Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50306503 (4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imid...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc Curated by ChEMBL					Assay Description Inhibition of recombinant GST-fused c-Met expressed in baculovirus infected high five cells by DELFIA				Bioorg Med Chem Lett 20: 848-52 (2010) Article DOI: 10.1016/j.bmcl.2009.12.099 BindingDB Entry DOI: 10.7270/Q2XW4JWR
MethylGene Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50306503 (4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imid...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met				Bioorg Med Chem Lett 20: 2745-9 (2010) Article DOI: 10.1016/j.bmcl.2010.03.073 BindingDB Entry DOI: 10.7270/Q24T6JJ6
MethylGene Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50306503 (4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imid...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc Curated by ChEMBL					Assay Description Inhibition of c-MET in human DU145 cells by scattering assay				Bioorg Med Chem Lett 20: 848-52 (2010) Article DOI: 10.1016/j.bmcl.2009.12.099 BindingDB Entry DOI: 10.7270/Q2XW4JWR
MethylGene Inc Curated by ChEMBL					More data for this Ligand-Target Pair