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BDBM50306677 (R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)acrylamide::CHEMBL602471

SMILES: C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl

InChI Key: InChIKey=OIOZTIQUNWLFQV-HVUAZKLTSA-N

Data: 25 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 50306677   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50306677
PNG
((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl |r|
Show InChI InChI=1S/C20H15Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h2-11H,1H3,(H2,24,26)/b7-2+/t11-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant PKCalpha by IMAP assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50306677
PNG
((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl |r|
Show InChI InChI=1S/C20H15Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h2-11H,1H3,(H2,24,26)/b7-2+/t11-/m1/s1
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n/an/a 23n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50306677
PNG
((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl |r|
Show InChI InChI=1S/C20H15Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h2-11H,1H3,(H2,24,26)/b7-2+/t11-/m1/s1
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n/an/a 20n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (Human))
BDBM50306677
PNG
((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl |r|
Show InChI InChI=1S/C20H15Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h2-11H,1H3,(H2,24,26)/b7-2+/t11-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant InsR by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50306677
PNG
((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl |r|
Show InChI InChI=1S/C20H15Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h2-11H,1H3,(H2,24,26)/b7-2+/t11-/m1/s1
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n/an/a 450n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant RON by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50306677
PNG
((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl |r|
Show InChI InChI=1S/C20H15Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h2-11H,1H3,(H2,24,26)/b7-2+/t11-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant Src by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM50306677
PNG
((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl |r|
Show InChI InChI=1S/C20H15Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h2-11H,1H3,(H2,24,26)/b7-2+/t11-/m1/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant Abl by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50306677
PNG
((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl |r|
Show InChI InChI=1S/C20H15Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h2-11H,1H3,(H2,24,26)/b7-2+/t11-/m1/s1
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n/an/a 6.40E+3n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant Aurora A by IMAP assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50306677
PNG
((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl |r|
Show InChI InChI=1S/C20H15Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h2-11H,1H3,(H2,24,26)/b7-2+/t11-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant AKT1 by IMAP assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 1


(Homo sapiens (Human))
BDBM50306677
PNG
((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl |r|
Show InChI InChI=1S/C20H15Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h2-11H,1H3,(H2,24,26)/b7-2+/t11-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant CDK1 by IMAP assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50306677
PNG
((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl |r|
Show InChI InChI=1S/C20H15Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h2-11H,1H3,(H2,24,26)/b7-2+/t11-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant CDK2 by IMAP assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50306677
PNG
((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl |r|
Show InChI InChI=1S/C20H15Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h2-11H,1H3,(H2,24,26)/b7-2+/t11-/m1/s1
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n/an/a 1.10E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant KDR by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BRK


(Homo sapiens (Human))
BDBM50306677
PNG
((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl |r|
Show InChI InChI=1S/C20H15Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h2-11H,1H3,(H2,24,26)/b7-2+/t11-/m1/s1
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n/an/a 3.20E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant BRK by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Yes


(Homo sapiens (Human))
BDBM50306677
PNG
((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl |r|
Show InChI InChI=1S/C20H15Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h2-11H,1H3,(H2,24,26)/b7-2+/t11-/m1/s1
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n/an/a 2.60E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant YES by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50306677
PNG
((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl |r|
Show InChI InChI=1S/C20H15Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h2-11H,1H3,(H2,24,26)/b7-2+/t11-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant EGFR by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50306677
PNG
((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl |r|
Show InChI InChI=1S/C20H15Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h2-11H,1H3,(H2,24,26)/b7-2+/t11-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant Kit by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50306677
PNG
((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl |r|
Show InChI InChI=1S/C20H15Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h2-11H,1H3,(H2,24,26)/b7-2+/t11-/m1/s1
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n/an/a 1.40E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant LCK by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50306677
PNG
((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl |r|
Show InChI InChI=1S/C20H15Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h2-11H,1H3,(H2,24,26)/b7-2+/t11-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant IGF1R by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM50306677
PNG
((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl |r|
Show InChI InChI=1S/C20H15Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h2-11H,1H3,(H2,24,26)/b7-2+/t11-/m1/s1
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n/an/a 2.80E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant Fyn by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM50306677
PNG
((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl |r|
Show InChI InChI=1S/C20H15Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h2-11H,1H3,(H2,24,26)/b7-2+/t11-/m1/s1
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n/an/a 3.20E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant Flt3 by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM50306677
PNG
((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl |r|
Show InChI InChI=1S/C20H15Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h2-11H,1H3,(H2,24,26)/b7-2+/t11-/m1/s1
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n/an/a 6.90E+3n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant FGFR2 by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Leukocyte tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50306677
PNG
((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl |r|
Show InChI InChI=1S/C20H15Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h2-11H,1H3,(H2,24,26)/b7-2+/t11-/m1/s1
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n/an/a 1.80E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant LTK by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Ephrin type-A receptor 2


(Homo sapiens (Human))
BDBM50306677
PNG
((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl |r|
Show InChI InChI=1S/C20H15Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h2-11H,1H3,(H2,24,26)/b7-2+/t11-/m1/s1
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n/an/a 4.40E+3n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant EphA2 by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM50306677
PNG
((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl |r|
Show InChI InChI=1S/C20H15Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h2-11H,1H3,(H2,24,26)/b7-2+/t11-/m1/s1
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n/an/a 570n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant AXL by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50306677
PNG
((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl |r|
Show InChI InChI=1S/C20H15Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h2-11H,1H3,(H2,24,26)/b7-2+/t11-/m1/s1
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n/an/a 2.60E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant KDR by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair