BDBM50306680 CHEMBL598912::rac-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)-N-methylacrylamide

SMILES: CNC(=O)\C=C\c1cnc2ccc(OC(C)c3c(Cl)ccc(F)c3Cl)cc2c1

InChI Key: InChIKey=WADWCVLVMLDBOV-FPYGCLRLSA-N

Data: 3 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50306680   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50306680 (CHEMBL598912 | rac-3-(6-(1-(2,6-dichloro-3-fluorop...) Show SMILES CNC(=O)\C=C\c1cnc2ccc(OC(C)c3c(Cl)ccc(F)c3Cl)cc2c1 Show InChI InChI=1S/C21H17Cl2FN2O2/c1-12(20-16(22)5-6-17(24)21(20)23)28-15-4-7-18-14(10-15)9-13(11-26-18)3-8-19(27)25-2/h3-12H,1-2H3,(H,25,27)/b8-3+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					Assay Description Inhibition of recombinant Src by TR-FRET assay				Bioorg Med Chem Lett 20: 1405-9 (2010) Article DOI: 10.1016/j.bmcl.2009.12.109 BindingDB Entry DOI: 10.7270/Q2HQ401G
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50306680 (CHEMBL598912 | rac-3-(6-(1-(2,6-dichloro-3-fluorop...) Show SMILES CNC(=O)\C=C\c1cnc2ccc(OC(C)c3c(Cl)ccc(F)c3Cl)cc2c1 Show InChI InChI=1S/C21H17Cl2FN2O2/c1-12(20-16(22)5-6-17(24)21(20)23)28-15-4-7-18-14(10-15)9-13(11-26-18)3-8-19(27)25-2/h3-12H,1-2H3,(H,25,27)/b8-3+	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					Assay Description Inhibition of recombinant c-Met by TR-FRET assay				Bioorg Med Chem Lett 20: 1405-9 (2010) Article DOI: 10.1016/j.bmcl.2009.12.109 BindingDB Entry DOI: 10.7270/Q2HQ401G
					More data for this Ligand-Target Pair				3D Structure (crystal)
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50306680 (CHEMBL598912 | rac-3-(6-(1-(2,6-dichloro-3-fluorop...) Show SMILES CNC(=O)\C=C\c1cnc2ccc(OC(C)c3c(Cl)ccc(F)c3Cl)cc2c1 Show InChI InChI=1S/C21H17Cl2FN2O2/c1-12(20-16(22)5-6-17(24)21(20)23)28-15-4-7-18-14(10-15)9-13(11-26-18)3-8-19(27)25-2/h3-12H,1-2H3,(H,25,27)/b8-3+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					Assay Description Inhibition of recombinant KDR by TR-FRET assay				Bioorg Med Chem Lett 20: 1405-9 (2010) Article DOI: 10.1016/j.bmcl.2009.12.109 BindingDB Entry DOI: 10.7270/Q2HQ401G
					More data for this Ligand-Target Pair