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BDBM50306888 4,6-dimethoxy-3-methyl-1H-pyrazolo[3,4-b]quinoline::CHEMBL603097::SCH-47089

SMILES: COc1ccc2nc3[nH]nc(C)c3c(OC)c2c1

InChI Key: InChIKey=AWSLSQGTMWLKRH-UHFFFAOYSA-N

Data: 5 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50306888
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Cyclin-dependent kinase 1 (Homo sapiens (Human))	BDBM50306888 (4,6-dimethoxy-3-methyl-1H-pyrazolo[3,4-b]quinoline...) Show SMILES COc1ccc2nc3[nH]nc(C)c3c(OC)c2c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Schering Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of CDC2				Bioorg Med Chem Lett 20: 1384-7 (2010) Article DOI: 10.1016/j.bmcl.2010.01.007 BindingDB Entry DOI: 10.7270/Q2QF8TTB
Schering Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50306888 (4,6-dimethoxy-3-methyl-1H-pyrazolo[3,4-b]quinoline...) Show SMILES COc1ccc2nc3[nH]nc(C)c3c(OC)c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Schering Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of CDK2				Bioorg Med Chem Lett 20: 1384-7 (2010) Article DOI: 10.1016/j.bmcl.2010.01.007 BindingDB Entry DOI: 10.7270/Q2QF8TTB
Schering Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50306888 (4,6-dimethoxy-3-methyl-1H-pyrazolo[3,4-b]quinoline...) Show SMILES COc1ccc2nc3[nH]nc(C)c3c(OC)c2c1 Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.14E+4	n/a	n/a	n/a	n/a	n/a	n/a
Schering Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of AKT				Bioorg Med Chem Lett 20: 1384-7 (2010) Article DOI: 10.1016/j.bmcl.2010.01.007 BindingDB Entry DOI: 10.7270/Q2QF8TTB
Schering Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50306888 (4,6-dimethoxy-3-methyl-1H-pyrazolo[3,4-b]quinoline...) Show SMILES COc1ccc2nc3[nH]nc(C)c3c(OC)c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Schering Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of AUR2				Bioorg Med Chem Lett 20: 1384-7 (2010) Article DOI: 10.1016/j.bmcl.2010.01.007 BindingDB Entry DOI: 10.7270/Q2QF8TTB
Schering Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4 (Homo sapiens (Human))	BDBM50306888 (4,6-dimethoxy-3-methyl-1H-pyrazolo[3,4-b]quinoline...) Show SMILES COc1ccc2nc3[nH]nc(C)c3c(OC)c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Schering Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of CDK4				Bioorg Med Chem Lett 20: 1384-7 (2010) Article DOI: 10.1016/j.bmcl.2010.01.007 BindingDB Entry DOI: 10.7270/Q2QF8TTB
Schering Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair