BindingDB PrimarySearch

BDBM50307395 12-(4-Phenyl[1,2,3]triazol-1-yl)dodecyl 2,3,4,6-Tetra-O-sulfor-D-mannopyranosyl-(1->3)-2,4,6-tri-O-sulfo-alpha-D-mannopyranosyl-(1->3)-2,4,6-tri-O-sulfo-alpha-D-mannopyranosyl-(1->3)-2,4,6-tri-O-sulfor-D-mannopyranosyl-(1->2)-3,4,6-tri-O-sulfo-alpha-D-mannopyranoside,HexadecasodiumSalt::CHEMBL590013

SMILES: [O-]S(=O)(=O)OC[C@H]1O[C@H](O[C@@H]2[C@@H](OCCCCCCCCCCCCn3cc(nn3)-c3ccccc3)O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]2OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H](O[C@H]2O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](O[C@H]3O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](O[C@H]4O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](OS([O-])(=O)=O)[C@@H]4OS([O-])(=O)=O)[C@@H]3OS([O-])(=O)=O)[C@@H]2OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O

InChI Key: InChIKey=ZMQXKELQMWICHL-NPCAVFQHSA-A

Data: 4 Kd

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50307395
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Heparanase (Homo sapiens (Human))	BDBM50307395 (12-(4-Phenyl[1,2,3]triazol-1-yl)dodecyl 2,3,4,6-Te...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a
Progen Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of human recombinant heparanase				J Med Chem 53: 1686-99 (2010) Article DOI: 10.1021/jm901449m BindingDB Entry DOI: 10.7270/Q2PG1SPH
Progen Pharmaceuticals Limited Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM50307395 (12-(4-Phenyl[1,2,3]triazol-1-yl)dodecyl 2,3,4,6-Te...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	5.10	n/a	n/a	n/a	n/a	n/a
Progen Pharmaceuticals Limited Curated by ChEMBL					Assay Description Binding affinity to VEGF by surface plasmon-based solution affinity assay				J Med Chem 53: 1686-99 (2010) Article DOI: 10.1021/jm901449m BindingDB Entry DOI: 10.7270/Q2PG1SPH
Progen Pharmaceuticals Limited Curated by ChEMBL					More data for this Ligand-Target Pair
Fibroblast growth factor 2 (Homo sapiens (Human))	BDBM50307395 (12-(4-Phenyl[1,2,3]triazol-1-yl)dodecyl 2,3,4,6-Te...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	253	n/a	n/a	n/a	n/a	n/a
Progen Pharmaceuticals Limited Curated by ChEMBL					Assay Description Binding affinity to FGF2 by surface plasmon-based solution affinity assay				J Med Chem 53: 1686-99 (2010) Article DOI: 10.1021/jm901449m BindingDB Entry DOI: 10.7270/Q2PG1SPH
Progen Pharmaceuticals Limited Curated by ChEMBL					More data for this Ligand-Target Pair
Acidic fibroblast growth factor (Homo sapiens (Human))	BDBM50307395 (12-(4-Phenyl[1,2,3]triazol-1-yl)dodecyl 2,3,4,6-Te...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a
Progen Pharmaceuticals Limited Curated by ChEMBL					Assay Description Binding affinity to FGF1 by surface plasmon-based solution affinity assay				J Med Chem 53: 1686-99 (2010) Article DOI: 10.1021/jm901449m BindingDB Entry DOI: 10.7270/Q2PG1SPH
Progen Pharmaceuticals Limited Curated by ChEMBL					More data for this Ligand-Target Pair