BDBM50307475 (1S,2R)-1-(3-Fluorophenyl)-3-(methylamino)-1-spiro[cyclohexane-1,30-indol]-1'(2'H)-ylpropan-2-ol Hydrochloride::CHEMBL602550

SMILES: CNC[C@@H](O)[C@@H](N1CC2(CCCCC2)c2ccccc12)c1cccc(F)c1

InChI Key: InChIKey=VSVCFDIMOHRRET-YADHBBJMSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50307475   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM50307475 ((1S,2R)-1-(3-Fluorophenyl)-3-(methylamino)-1-spiro...) Show SMILES CNC[C@@H](O)[C@@H](N1CC2(CCCCC2)c2ccccc12)c1cccc(F)c1 |r| Show InChI InChI=1S/C23H29FN2O/c1-25-15-21(27)22(17-8-7-9-18(24)14-17)26-16-23(12-5-2-6-13-23)19-10-3-4-11-20(19)26/h3-4,7-11,14,21-22,25,27H,2,5-6,12-13,15-16H2,1H3/t21-,22+/m1/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.92E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of serotonin uptake at human SERT expressed in human JAR cells				J Med Chem 53: 2051-62 (2010) Article DOI: 10.1021/jm901559e BindingDB Entry DOI: 10.7270/Q21J99VS
					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM50307475 ((1S,2R)-1-(3-Fluorophenyl)-3-(methylamino)-1-spiro...) Show SMILES CNC[C@@H](O)[C@@H](N1CC2(CCCCC2)c2ccccc12)c1cccc(F)c1 |r| Show InChI InChI=1S/C23H29FN2O/c1-25-15-21(27)22(17-8-7-9-18(24)14-17)26-16-23(12-5-2-6-13-23)19-10-3-4-11-20(19)26/h3-4,7-11,14,21-22,25,27H,2,5-6,12-13,15-16H2,1H3/t21-,22+/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cells				J Med Chem 53: 2051-62 (2010) Article DOI: 10.1021/jm901559e BindingDB Entry DOI: 10.7270/Q21J99VS
					More data for this Ligand-Target Pair