BDBM50307945 4-(4-tert-Butylbenzyl)-1-(1H-pyrazolo[3,4-b]pyridin-4-yl)piperidin-4-amine::CHEMBL603675

SMILES: CC(C)(C)c1ccc(CC2(N)CCN(CC2)c2ccnc3[nH]ncc23)cc1

InChI Key: InChIKey=ZSPYHLIIAPFXSZ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50307945   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50307945 (4-(4-tert-Butylbenzyl)-1-(1H-pyrazolo[3,4-b]pyridi...) Show SMILES CC(C)(C)c1ccc(CC2(N)CCN(CC2)c2ccnc3[nH]ncc23)cc1 Show InChI InChI=1S/C22H29N5/c1-21(2,3)17-6-4-16(5-7-17)14-22(23)9-12-27(13-10-22)19-8-11-24-20-18(19)15-25-26-20/h4-8,11,15H,9-10,12-14,23H2,1-3H3,(H,24,25,26)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.5	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of PKB in human U87MG cells assessed as GSK3beta phosphorylation by ELISA				J Med Chem 53: 2239-49 (2010) Article DOI: 10.1021/jm901788j BindingDB Entry DOI: 10.7270/Q23B608V
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase AKT2 (Homo sapiens (Human))	BDBM50307945 (4-(4-tert-Butylbenzyl)-1-(1H-pyrazolo[3,4-b]pyridi...) Show SMILES CC(C)(C)c1ccc(CC2(N)CCN(CC2)c2ccnc3[nH]ncc23)cc1 Show InChI InChI=1S/C22H29N5/c1-21(2,3)17-6-4-16(5-7-17)14-22(23)9-12-27(13-10-22)19-8-11-24-20-18(19)15-25-26-20/h4-8,11,15H,9-10,12-14,23H2,1-3H3,(H,24,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	58	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of PKBbeta by radiometric filter binding assay				J Med Chem 53: 2239-49 (2010) Article DOI: 10.1021/jm901788j BindingDB Entry DOI: 10.7270/Q23B608V
					More data for this Ligand-Target Pair